Reactome | SHP1 and SHP2 dephosphorylate Y628 of IL3RB

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SHP1 and SHP2 dephosphorylate Y628 of IL3RB Show undefined attributes

authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
catalystActivity	[CatalystActivity:914051] protein tyrosine phosphatase activity of High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:914066] Jupe, S, 2010-07-21
dbId	914036
displayName	SHP1 and SHP2 dephosphorylate Y628 of IL3RB
edited	[InstanceEdit:927712] Jupe, S, 2010-08-06
eventOf	[Pathway:R-HSA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling - Homo sapiens
input	[Complex:R-HSA-914086] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:909748] SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	SHP1 and SHP2 dephosphorylate Y628 of IL3RB
orthologousEvent	[Reaction:R-GGA-914036] SHP1 and SHP2 dephosphorylate Y628 of IL3RB - Gallus gallus [Reaction:R-SSC-914036] SHP1 and SHP2 dephosphorylate Y628 of IL3RB - Sus scrofa [Reaction:R-BTA-914036] SHP1 and SHP2 dephosphorylate Y628 of IL3RB - Bos taurus [Reaction:R-CFA-914036] SHP1 and SHP2 dephosphorylate Y628 of IL3RB - Canis familiaris [Reaction:R-RNO-914036] SHP1 and SHP2 dephosphorylate Y628 of IL3RB - Rattus norvegicus [Reaction:R-MMU-914036] SHP1 and SHP2 dephosphorylate Y628 of IL3RB - Mus musculus
output	[Complex:R-HSA-914049] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-909738] SHP1 and SHP2 bind the common beta chain - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:941869] Lopez, AF, 2010-09-06 [InstanceEdit:941867] Hercus, TR, 2010-09-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-914036
summation	[Summation:914029] Synthetic phosphopeptides based on Bc were dephosphorylated ...

Referrals

(hasEvent)

[Pathway:R-HSA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling