Reactome | SHP1 and SHP2 dephosphorylate Y628 of IL3RB

SHP1 and SHP2 dephosphorylate Y628 of IL3RB

Stable Identifier

R-HSA-914036

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SHP1 and SHP2 dephosphorylate Y628 of IL3RB

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Synthetic phosphopeptides based on Bc were dephosphorylated by SHP1 and SHP2, peptides phosphorylated at Y628 were the best substrate followed by those phosphorylated at Y766.

Literature References

PubMed ID	Title	Journal	Year
9162089	SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates Dechert, U, Jirik, F, Bone, H, Welham, MJ, Schrader, JW	J Biol Chem	1997

Participants

Input

High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)

Output

High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)

Participates

as an event of

Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)

Catalyst Activity

protein tyrosine phosphatase activity of High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane]

Physical Entity

High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)

Activity

protein tyrosine phosphatase activity (GO:0004725)

Orthologous Events

SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Bos taurus)

SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Canis familiaris)

SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Gallus gallus)

SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Mus musculus)

SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Rattus norvegicus)

SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Sus scrofa)

Authored