Reactome | ATR phosphorylates Histone H2A.X at unsynapsed regions

Schema > Reaction > Entries

ATR phosphorylates Histone H2A.X at unsynapsed regions Show undefined attributes

authored	[InstanceEdit:913923] May, B, 2010-07-19
catalystActivity	[CatalystActivity:912432] protein serine/threonine kinase activity of Synaptonemal Complex:BRCA1:ATR [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:912491] May, B, 2010-07-08
dbId	912470
displayName	ATR phosphorylates Histone H2A.X at unsynapsed regions
edited	[InstanceEdit:913923] May, B, 2010-07-19
eventOf	[Pathway:R-HSA-1221632] Meiotic synapsis - Homo sapiens
inferredFrom	[Reaction:R-MMU-912423] Atr Phosphorylates Histone H2A.X at Unsynapsed Regions - Mus musculus
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-975778] Unsynapsed chromatin [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:912457] ATR, BRCA1 and gammaH2AX localize to unsynapsed chromosomes at the pachytene stage in human oocytes [LiteratureReference:913816] Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ATR phosphorylates Histone H2A.X at unsynapsed regions
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-975781] Unsynapsed chromatin with gamma-H2A.x [nucleoplasm]
precedingEvent	[Reaction:R-HSA-912450] ATR Kinase is recruited to unsynapsed regions - Homo sapiens
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1221628] Bolcun-Filas, E, 2011-02-25 [InstanceEdit:1181360] Cohen, PE, 2011-02-04 [InstanceEdit:1181371] Holloway, JK, 2011-02-04 [InstanceEdit:1221625] Lyndaker, A, 2011-02-25 [InstanceEdit:1181380] Schimenti, JC, 2011-02-04 [InstanceEdit:1221623] Strong, E, 2011-02-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-912470
summation	[Summation:914120] The ATR kinase phosphorylates histone H2A.X at serine 139 (W...

Referrals

(hasEvent)	[Pathway:R-HSA-1221632] Meiotic synapsis
(inferredTo)	[Reaction:R-MMU-912423] Atr Phosphorylates Histone H2A.X at Unsynapsed Regions

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