Reactome | PRDM9 binds recombination hotspot motifs in DNA

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PRDM9 binds recombination hotspot motifs in DNA Show undefined attributes

authored	[InstanceEdit:913923] May, B, 2010-07-19
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:912369] May, B, 2010-07-08
dbId	912363
displayName	PRDM9 binds recombination hotspot motifs in DNA
edited	[InstanceEdit:913923] May, B, 2010-07-19
eventOf	[Pathway:R-HSA-912446] Meiotic recombination - Homo sapiens
followingEvent	[Reaction:R-HSA-1214188] PRDM9 trimethylates histone H3 - Homo sapiens
inferredFrom	[Reaction:R-MMU-912383] Prdm9 Binds Recombination Hotspot Motifs in DNA - Mus musculus
input	[OtherEntity:R-ALL-29428] DNA [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-912345] PRDM9 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:912339] PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice [LiteratureReference:913218] Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination [LiteratureReference:1181378] PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PRDM9 binds recombination hotspot motifs in DNA
output	[Complex:R-HSA-912415] PRDM9:DNA [nucleoplasm]
releaseDate	2011-03-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1221628] Bolcun-Filas, E, 2011-02-25 [InstanceEdit:1181360] Cohen, PE, 2011-02-04 [InstanceEdit:1181371] Holloway, JK, 2011-02-04 [InstanceEdit:1221625] Lyndaker, A, 2011-02-25 [InstanceEdit:1181380] Schimenti, JC, 2011-02-04 [InstanceEdit:1221623] Strong, E, 2011-02-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-912363
summation	[Summation:914100] PR-domain containing 9 (PRDM9) protein is a meiosis specific...

Referrals

(hasEvent)	[Pathway:R-HSA-912446] Meiotic recombination
(precedingEvent)	[Reaction:R-HSA-1214188] PRDM9 trimethylates histone H3
(inferredTo)	[Reaction:R-MMU-912383] Prdm9 Binds Recombination Hotspot Motifs in DNA

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