Reactome | GAA hydrolyzes lysosomal glycogen

Schema > Reaction > Entries

GAA hydrolyzes lysosomal glycogen Show undefined attributes

authored	[InstanceEdit:5357603] D'Eustachio, Peter, 2014-03-24
catalystActivity	[CatalystActivity:5357535] alpha-glucosidase activity of GAA (70, 76 kDa) [lysosomal lumen]
catalystActivityReference	[CatalystActivityReference:9643896] alpha-glucosidase activity of GAA (70, 76 kDa) [lysosomal lumen] Simultaneous absence of alpha-1,4-glucosidase and alpha-1,6-glucosidase activities (pH 4) in tissues of children with type II glycogen storage disease
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:9036730] D'Eustachio, Peter, 2018-02-07
dbId	9036727
deleted	[Deleted:9036737] Deletion of instances: 5357589, 5357585, 5357572
diseaseReaction	[FailedReaction:R-HSA-9036729] Defective GAA does not hydrolyze lysosomal glycogen - Homo sapiens
displayName	GAA hydrolyzes lysosomal glycogen
edited	[InstanceEdit:5357603] D'Eustachio, Peter, 2014-03-24
eventOf	[Pathway:R-HSA-70221] Glycogen breakdown (glycogenolysis) - Homo sapiens
input	[Complex:R-HSA-9036726] glycogen-GYG1 dimer [lysosomal lumen] 2 × [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5357552] Simultaneous absence of alpha-1,4-glucosidase and alpha-1,6-glucosidase activities (pH 4) in tissues of children with type II glycogen storage disease [LiteratureReference:5357537] Primary structure and processing of lysosomal alpha-glucosidase; homology with the intestinal sucrase-isomaltase complex [LiteratureReference:5357581] Specific functions of lysosomal proteases in endocytic and autophagic pathways [LiteratureReference:5357559] Structural and functional changes of lysosomal acid alpha-glucosidase during intracellular transport and maturation
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	GAA hydrolyzes lysosomal glycogen GAA hydrolyzes alpha(1,6) linkages in lysosomal glycogen GAA hydrolyzes alpha(1,4) linkages in lysosomal glycogen
orthologousEvent	[Reaction:R-MMU-9036727] GAA hydrolyzes lysosomal glycogen - Mus musculus [Reaction:R-SPO-9036727] GAA hydrolyzes lysosomal glycogen - Schizosaccharomyces pombe [Reaction:R-GGA-9036727] GAA hydrolyzes lysosomal glycogen - Gallus gallus [Reaction:R-SSC-9036727] GAA hydrolyzes lysosomal glycogen - Sus scrofa [Reaction:R-BTA-9036727] GAA hydrolyzes lysosomal glycogen - Bos taurus [Reaction:R-CFA-9036727] GAA hydrolyzes lysosomal glycogen - Canis familiaris [Reaction:R-RNO-9036727] GAA hydrolyzes lysosomal glycogen - Rattus norvegicus
output	2 × [SimpleEntity:R-ALL-1605745] Glc [lysosomal lumen] [Complex:R-HSA-5357533] poly((1,4)-alpha-glucosyl)GYG1 dimer [lysosomal lumen]
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5358504] Jassal, Bijay, 2014-03-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9036727
summation	[Summation:5357587] While most glycogen is cytosolic, glycogen granules are also...

Referrals

(replacementInstances)	[Deleted:9036737] Deletion of instances: 5357589, 5357585, 5357572
(normalReaction)	[FailedReaction:R-HSA-9036729] Defective GAA does not hydrolyze lysosomal glycogen
(hasEvent)	[Pathway:R-HSA-70221] Glycogen breakdown (glycogenolysis)

Cite Us!