Reactome | Defective HYAL1 does not hydrolyse (HA)50

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Defective HYAL1 does not hydrolyse (HA)50 Show undefined attributes

authored	[InstanceEdit:2318591] Jassal, B, 2012-06-14
catalystActivity	[CatalystActivity:9631888] hyalurononglucosaminidase activity of HYAL1 mutants [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:2318591] Jassal, B, 2012-06-14
crossReference	[DatabaseIdentifier:12020936] Mondo:0019249
dbId	9036077
disease	[Disease:2226052] mucopolysaccharidosis
displayName	Defective HYAL1 does not hydrolyse (HA)50
edited	[InstanceEdit:2318591] Jassal, B, 2012-06-14
entityFunctionalStatus	[EntityFunctionalStatus:2318590] loss_of_function of HYAL1 mutants [lysosomal lumen]
eventOf	[Pathway:R-HSA-2206280] MPS IX - Natowicz syndrome (Hyaluronan metabolism) - Homo sapiens
input	[Polymer:R-ALL-2160864] (HA)50 [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2318602] Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective HYAL1 does not hydrolyse (HA)50
normalReaction	[BlackBoxEvent:R-HSA-2160874] HYAL1 hydrolyses (HA)50
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2457644] Coutinho, Maria, 2012-08-27 [InstanceEdit:2457645] Alves, Sandra, 2012-08-27
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9036077
summation	[Summation:9036078] In the acidic environment of the lysosome, hyaluronidase 1 (...
updateTrackers	[UpdateTracker:9777841] Update Tracker - [FailedReaction:9036077] Defective HYAL1 does not hydrolyse (HA)50 - v68:[addCatalystActivity] [UpdateTracker:9835766] Update Tracker - [FailedReaction:9036077] Defective HYAL1 does not hydrolyse (HA)50 - v85:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777841] Update Tracker - [FailedReaction:9036077] Defective HYAL1 does not hydrolyse (HA)50 - v68:[addCatalystActivity] [UpdateTracker:9835766] Update Tracker - [FailedReaction:9036077] Defective HYAL1 does not hydrolyse (HA)50 - v85:[modifyText]
(hasEvent)	[Pathway:R-HSA-2206280] MPS IX - Natowicz syndrome (Hyaluronan metabolism)

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