Reactome | Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix

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Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix Show undefined attributes

authored	[InstanceEdit:9033239] May, Bruce, 2017-12-18
category	uncertain
compartment	[Compartment:17947] peroxisomal membrane
created	[InstanceEdit:9033234] May, Bruce, 2017-12-19
dbId	9033235
displayName	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix
edited	[InstanceEdit:9033239] May, Bruce, 2017-12-18
eventOf	[Pathway:R-HSA-9033241] Peroxisomal protein import - Homo sapiens
followingEvent	[Reaction:R-HSA-9033524] TYSND1 cleaves SCP2 - Homo sapiens [Reaction:R-HSA-9033520] TYSND1 cleaves TYSND1 - Homo sapiens [Reaction:R-HSA-9033530] TYSND1 cleaves HSD17B4 - Homo sapiens [Reaction:R-HSA-9033515] TYSND1 cleaves ACOX1 - Homo sapiens [Reaction:R-HSA-8953917] PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 - Homo sapiens
input	[Complex:R-HSA-9033114] PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9033066] A cargo-centered perspective on the PEX5 receptor-mediated peroxisomal protein import pathway [LiteratureReference:9033018] Mapping the cargo protein membrane translocation step into the PEX5 cycling pathway [LiteratureReference:9033006] Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders [LiteratureReference:9033629] The energetics of Pex5p-mediated peroxisomal protein import [LiteratureReference:9033903] Genotype-phenotype correlation in PEX5-deficient peroxisome biogenesis defective cell lines [LiteratureReference:9033000] The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo [LiteratureReference:9033031] Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders [LiteratureReference:9034442] Protein transport into peroxisomes: Knowns and unknowns [LiteratureReference:9033827] A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix
orthologousEvent	[BlackBoxEvent:R-SCE-9033235] Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix - Saccharomyces cerevisiae [BlackBoxEvent:R-SPO-9033235] Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix - Schizosaccharomyces pombe [BlackBoxEvent:R-DDI-9033235] Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix - Dictyostelium discoideum [BlackBoxEvent:R-DME-9033235] Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix - Drosophila melanogaster [BlackBoxEvent:R-GGA-9033235] Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix - Gallus gallus [BlackBoxEvent:R-XTR-9033235] Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix - Xenopus tropicalis [BlackBoxEvent:R-SSC-9033235] Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix - Sus scrofa [BlackBoxEvent:R-BTA-9033235] Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix - Bos taurus [BlackBoxEvent:R-CFA-9033235] Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix - Canis familiaris [BlackBoxEvent:R-RNO-9033235] Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix - Rattus norvegicus [BlackBoxEvent:R-MMU-9033235] Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix - Mus musculus
output	[DefinedSet:R-HSA-9033148] Cargo proteins containing PTS1 [peroxisomal matrix] [Complex:R-HSA-9033091] PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane]
precedingEvent	[Reaction:R-HSA-9033236] PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) - Homo sapiens
releaseDate	2018-03-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9036917] Fransen, Marc, 2018-02-13 [InstanceEdit:9036916] Van Veldhoven, Paul P, 2018-02-13 [InstanceEdit:9038621] Azevedo, Jorge E, 2018-03-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9033235
summation	[Summation:9033602] After binding the Docking and Translocation Module comprisin...
updateTrackers	[UpdateTracker:9779386] Update Tracker - [BlackBoxEvent:9033235] Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix - v65:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9779386] Update Tracker - [BlackBoxEvent:9033235] Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix - v65:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-9033241] Peroxisomal protein import
(precedingEvent)	[Reaction:R-HSA-9033524] TYSND1 cleaves SCP2 [Reaction:R-HSA-9033520] TYSND1 cleaves TYSND1 [Reaction:R-HSA-9033530] TYSND1 cleaves HSD17B4 [Reaction:R-HSA-9033515] TYSND1 cleaves ACOX1 [Reaction:R-HSA-8953917] PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3

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