Reactome | PEX5S,L binds cargo proteins containing PTS1

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PEX5S,L binds cargo proteins containing PTS1 Show undefined attributes

authored	[InstanceEdit:9032610] May, Bruce, 2017-12-15
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9033234] May, Bruce, 2017-12-19
dbId	9033233
displayName	PEX5S,L binds cargo proteins containing PTS1
edited	[InstanceEdit:9032610] May, Bruce, 2017-12-15
eventOf	[Pathway:R-HSA-9033241] Peroxisomal protein import - Homo sapiens
followingEvent	[Reaction:R-HSA-9033236] PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) - Homo sapiens
inferredFrom	[Reaction:R-MMU-9033925] Pex5l binds Acox1 or Uox - Mus musculus
input	[DefinedSet:R-HSA-9033111] Cargo proteins containing PTS1 [cytosol] [DefinedSet:R-HSA-9033603] PEX5S,L [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9033040] Correlating structure and affinity for PEX5:PTS1 complexes [LiteratureReference:9033008] PEX5 binds the PTS1 independently of Hsp70 and the peroxin PEX12 [LiteratureReference:9033051] Protein structure and import into the peroxisomal matrix [LiteratureReference:9033049] Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5 [LiteratureReference:9033031] Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders [LiteratureReference:9033006] Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders [LiteratureReference:9033021] PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14 [LiteratureReference:9033011] A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities [LiteratureReference:9033508] Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid ?-oxidation in peroxisomal matrix [LiteratureReference:9036551] Characterization of the yeast and human receptors for the carboxy-terminal tripeptide peroxisomal targeting signal [LiteratureReference:9036588] Pex5p imports folded tetrameric catalase by interaction with Pex13p [LiteratureReference:9036902] The difference in recognition of terminal tripeptides as peroxisomal targeting signal 1 between yeast and human is due to different affinities of their receptor Pex5p to the cognate signal and to residues adjacent to it [LiteratureReference:9036901] Peroxisome targeting signal 1: is it really a simple tripeptide? [LiteratureReference:9033043] Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import [LiteratureReference:9033036] An isoform of pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes [LiteratureReference:9033919] The peroxisomal protein import machinery displays a preference for monomeric substrates [LiteratureReference:9033827] A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PEX5S,L binds cargo proteins containing PTS1
output	[Complex:R-HSA-9033153] PEX5S,L:Cargo protein [cytosol]
releaseDate	2018-03-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9036917] Fransen, Marc, 2018-02-13 [InstanceEdit:9036916] Van Veldhoven, Paul P, 2018-02-13 [InstanceEdit:9038621] Azevedo, Jorge E, 2018-03-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9033233
summation	[Summation:9033620] It is unclear how the long isoform of PEX5 (PEX5L) and the s...
updateTrackers	[UpdateTracker:9779484] Update Tracker - [Reaction:9033233] PEX5S,L binds cargo proteins containing PTS1 - v65:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9779484] Update Tracker - [Reaction:9033233] PEX5S,L binds cargo proteins containing PTS1 - v65:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-9033241] Peroxisomal protein import
(precedingEvent)	[Reaction:R-HSA-9033236] PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)
(inferredTo)	[Reaction:R-MMU-9033925] Pex5l binds Acox1 or Uox

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