Reactome | NR1H2,3, NRIP1 bind the FASN gene

Schema > Reaction > Entries

NR1H2,3, NRIP1 bind the FASN gene Show undefined attributes

authored	[InstanceEdit:9035107] Shamovsky, Veronica, 2018-01-18
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9028531] Shamovsky, Veronica, 2017-11-09
dbId	9028533
displayName	NR1H2,3, NRIP1 bind the FASN gene
edited	[InstanceEdit:9657765] Shamovsky, Veronica, 2019-08-09
eventOf	[Pathway:R-HSA-9029558] NR1H2 & NR1H3 regulate gene expression linked to lipogenesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9605063] Expression of FASN regulated by NR1H2 or NR1H3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2393979] FASN gene [nucleoplasm] [CandidateSet:R-HSA-9024381] NR1H2,3:RXR [nucleoplasm] [DefinedSet:R-ALL-9024383] NR1H3, NR1H2 ligands [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-4086031] NRIP1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9028536] The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor [LiteratureReference:9024431] Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NR1H2,3, NRIP1 bind the FASN gene LXR, NRIP1 bind the FASN gene
output	[Complex:R-HSA-9028534] NRIP1:NR1H2,3:RXR:NR1H2,3 ligand:FASN gene [nucleoplasm]
releaseDate	2019-09-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9633727] D'Eustachio, Peter, 2018-12-29 [InstanceEdit:9657850] Cummins, Carolyn L, Repa, Joyce J, 2019-08-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9028533
summation	[Summation:9029526] Fatty acid synthase (FAS or FASN) is a central enzyme in de ...

Referrals

(hasEvent)	[Pathway:R-HSA-9029558] NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
(precedingEvent)	[BlackBoxEvent:R-HSA-9605063] Expression of FASN regulated by NR1H2 or NR1H3

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