Reactome | MECP2 binds 5hmC-DNA

Schema > Reaction > Entries

authored	[InstanceEdit:9024208] Orlic-Milacic, Marija, 2017-10-02
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9022450] Orlic-Milacic, Marija, 2017-09-22
dbId	9022453
diseaseReaction	[FailedReaction:R-HSA-9022462] MECP2 mutants R133C ,D121G, R133H and S134F do not bind 5hmC-DNA - Homo sapiens
displayName	MECP2 binds 5hmC-DNA
edited	[InstanceEdit:9615799] Orlic-Milacic, Marija, 2018-08-08
eventOf	[Pathway:R-HSA-8986944] Transcriptional Regulation by MECP2 - Homo sapiens
input	[GenomeEncodedEntity:R-HSA-9022446] 5hmC-DNA [nucleoplasm] [CandidateSet:R-HSA-9005549] MECP2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9022452] MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MECP2 binds 5hmC-DNA
output	[Complex:R-HSA-9022466] MECP2:5hmC-DNA [nucleoplasm]
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608119] Krishnaraj, Rahul, 2018-08-07 [InstanceEdit:9608114] Christodoulou, John, 2018-08-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9022453
summation	[Summation:9022455] MECP2 binds to DNA containing 5-hydroxymethylcytosine (5hmC-...

(normalReaction)	[FailedReaction:R-HSA-9022462] MECP2 mutants R133C ,D121G, R133H and S134F do not bind 5hmC-DNA
(hasEvent)	[Pathway:R-HSA-8986944] Transcriptional Regulation by MECP2

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