MECP2 binds 5hmC-DNA

Stable Identifier
R-HSA-9022453
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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MECP2 binds 5hmC-DNA
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MECP2 binds to DNA containing 5-hydroxymethylcytosine (5hmC-DNA), a DNA modification associated with transcriptional activation (Mellen et al. 2012).

Literature References
PubMed ID Title Journal Year
23260135 MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system

Mellén, M, Ayata, P, Dewell, S, Kriaucionis, S, Heintz, N

Cell 2012
Participants
Input
Output
Participant Of
hasEvent
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-22)