Reactome | LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2

Schema > Reaction > Entries

LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 Show undefined attributes

authored	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
catalystActivity	[CatalystActivity:9022649] epoxide hydrolase activity of LTA4H:Zn2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
dbId	9020258
displayName	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2
edited	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
eventOf	[Pathway:R-HSA-9018676] Biosynthesis of D-series resolvins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9024785] RvD1-6 translocate from cytosol to extracellular region - Homo sapiens [Reaction:R-HSA-9024766] HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1 - Homo sapiens
input	[SimpleEntity:R-ALL-9024768] 7S(8)-epoxy-17(S)-HDHA [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9024597] Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis [LiteratureReference:9024464] Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation [LiteratureReference:9022657] Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2
orthologousEvent	[Reaction:R-SCE-9020258] LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 - Saccharomyces cerevisiae [Reaction:R-SPO-9020258] LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 - Schizosaccharomyces pombe [Reaction:R-DDI-9020258] LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 - Dictyostelium discoideum [Reaction:R-CEL-9020258] LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 - Caenorhabditis elegans [Reaction:R-DME-9020258] LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 - Drosophila melanogaster [Reaction:R-GGA-9020258] LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 - Gallus gallus [Reaction:R-XTR-9020258] LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 - Xenopus tropicalis [Reaction:R-DRE-9020258] LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 - Danio rerio [Reaction:R-SSC-9020258] LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 - Sus scrofa [Reaction:R-BTA-9020258] LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 - Bos taurus [Reaction:R-CFA-9020258] LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 - Canis familiaris [Reaction:R-RNO-9020258] LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 - Rattus norvegicus [Reaction:R-MMU-9020258] LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2 - Mus musculus
output	[DefinedSet:R-ALL-9024759] RvD1, RvD2 [cytosol]
precedingEvent	[Reaction:R-HSA-9020255] ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9020258
summation	[Summation:9024761] Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enz...

Referrals

(hasEvent)	[Pathway:R-HSA-9018676] Biosynthesis of D-series resolvins
(precedingEvent)	[BlackBoxEvent:R-HSA-9024785] RvD1-6 translocate from cytosol to extracellular region [Reaction:R-HSA-9024766] HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1

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