LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2

Stable Identifier
R-HSA-9020258
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 7S(8)-epoxy-17(S)-hydroxydocosahexaenoic acid (7S(8)-epoxy-17(S)-HDHA) to the trihydroxydocosahexaenoic acids 7(S), 8(R), 17(S)-triHDHA and 7(S), 16(R), 17(S)-triHDHA (RvD1 and RvD2 respectively) (Sun et al. 2007, Spite et al. 2009, Serhan et al. 2002). The D-resolvins are anti-inflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008).

Literature References
PubMed ID Title Journal Year
17244615 Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation

Sun, YP, Oh, SF, Uddin, J, Yang, R, Gotlinger, K, Campbell, E, Colgan, SP, Petasis, NA, Serhan, CN

J. Biol. Chem. 2007
19865173 Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

Spite, M, Norling, LV, Summers, L, Yang, R, Cooper, D, Petasis, NA, Flower, RJ, Perretti, M, Serhan, CN

Nature 2009
12391014 Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals

Serhan, CN, Hong, S, Gronert, K, Colgan, SP, Devchand, PR, Mirick, G, Moussignac, RL

J. Exp. Med. 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
epoxide hydrolase activity of LTA4H:Zn2+ [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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