Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 7S(8)-epoxy-17(S)-hydroxydocosahexaenoic acid (7S(8)-epoxy-17(S)-HDHA) to the trihydroxydocosahexaenoic acids 7(S), 8(R), 17(S)-triHDHA and 7(S), 16(R), 17(S)-triHDHA (RvD1 and RvD2 respectively) (Sun et al. 2007, Spite et al. 2009, Serhan et al. 2002). The D-resolvins are anti-inflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008).