Reactome | RHOT1 GEFs activate RHOT1

Schema > Reaction > Entries

authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14
catalystActivity	[CatalystActivity:9020450] guanyl-nucleotide exchange factor activity of RAP1GDS1 [mitochondrial outer membrane]
category	transition
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:70101] cytosol
created	[InstanceEdit:9018816] Orlic-Milacic, Marija, 2017-09-05
dbId	9018817
displayName	RHOT1 GEFs activate RHOT1
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25
eventOf	[Pathway:R-HSA-9013425] RHOT1 GTPase cycle - Homo sapiens
followingEvent	[Reaction:R-HSA-9018814] RHOT1 hydrolyzes GTP - Homo sapiens [Reaction:R-HSA-9018815] RHOT1 binds effectors at the mitochondrial outer membrane - Homo sapiens
inferredFrom	[Reaction:R-DME-9693775] Vimar activates Miro - Drosophila melanogaster
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-9020412] RHOT1:GDP [mitochondrial outer membrane]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RHOT1 GEFs activate RHOT1
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-9020413] RHOT1:GTP [mitochondrial outer membrane]
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9714635] Schrader, Michael, 2021-02-09 [InstanceEdit:9714634] Castro, In�s G, 2021-02-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9018817
summation	[Summation:9693764] Based on studies in Drosophila, RAP1GDS1, an orthologue of D...

(hasEvent)	[Pathway:R-HSA-9013425] RHOT1 GTPase cycle
(precedingEvent)	[Reaction:R-HSA-9018814] RHOT1 hydrolyzes GTP [Reaction:R-HSA-9018815] RHOT1 binds effectors at the mitochondrial outer membrane
(inferredTo)	[Reaction:R-DME-9693775] Vimar activates Miro

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