Reactome | FOXA1 and GATA3 bind TFF genes

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FOXA1 and GATA3 bind TFF genes Show undefined attributes

authored	[InstanceEdit:9024061] Rothfels, Karen, 2017-09-29
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9018495] Rothfels, Karen, 2017-09-01
dbId	9018494
displayName	FOXA1 and GATA3 bind TFF genes
edited	[InstanceEdit:9028899] Rothfels, Karen, 2017-11-13
eventOf	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression - Homo sapiens
followingEvent	[Reaction:R-HSA-9009541] ESR1 binds to TFF1 gene promoter - Homo sapiens [Reaction:R-HSA-9018499] ESR1:ESTG and EP300 are recruited to TFF3 promoter - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-453074] FOXA1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-996768] GATA3 [nucleoplasm] [DefinedSet:R-HSA-9018486] TFF1, TFF3 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9018474] Trefoil factor family peptides--friends or foes? [LiteratureReference:9018402] Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequence [LiteratureReference:9023044] Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription [LiteratureReference:9008273] Estrogen receptor interaction with estrogen response elements [LiteratureReference:9008985] Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1 [LiteratureReference:9009027] From the Cover: Location analysis of estrogen receptor alpha target promoters reveals that FOXA1 defines a domain of the estrogen response [LiteratureReference:9008977] A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer [LiteratureReference:9009018] FOXA1 is a key determinant of estrogen receptor function and endocrine response [LiteratureReference:9008982] Cellular reprogramming by the conjoint action of ER?, FOXA1, and GATA3 to a ligand-inducible growth state [LiteratureReference:9011791] GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility [LiteratureReference:9009039] Pioneer transcription factors: establishing competence for gene expression [LiteratureReference:9009020] FOXA1: master of steroid receptor function in cancer [LiteratureReference:9008989] Cooperating transcription factors mediate the function of estrogen receptor [LiteratureReference:9009035] Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor alpha pathway [LiteratureReference:9018447] Histone modifications at human enhancers reflect global cell-type-specific gene expression [LiteratureReference:9018412] Histone H3K27ac separates active from poised enhancers and predicts developmental state
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FOXA1 and GATA3 bind TFF genes
output	[DefinedSet:R-HSA-9023829] TFF1,TFF3 gene:FOXA1:GATA3 [nucleoplasm]
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9038169] Magnani, Luca, 2018-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9018494
summation	[Summation:9018469] Trefoil factor family (TFF) 1 and 3 are secreted in mucous e...

Referrals

(hasEvent)	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression
(precedingEvent)	[Reaction:R-HSA-9009541] ESR1 binds to TFF1 gene promoter [Reaction:R-HSA-9018499] ESR1:ESTG and EP300 are recruited to TFF3 promoter

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