Reactome | Negative regulation by 'p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]'

Schema > NegativeRegulation > Entries

activeUnit	[Complex:R-HSA-8942837] p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] - Homo sapiens
created	[InstanceEdit:9018019] Orlic-Milacic, Marija, 2017-08-29
dbId	9018018
displayName	Negative regulation by 'p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]'
modified	[InstanceEdit:9608020] Wu, G, 2018-05-08
regulatedEntity	[FailedReaction:R-HSA-9659782] Defective RB1 does not bind E2F1,(E2F2,E2F3) - Homo sapiens [Reaction:R-HSA-9018017] RB1 binds and inhibits E2F1/2/3:DP1/2 complexes - Homo sapiens
regulator	[CandidateSet:R-HSA-8949896] p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
schemaClass	NegativeRegulation
stId	R-HSA-9018018

(regulatedBy)	[FailedReaction:R-HSA-9659782] Defective RB1 does not bind E2F1,(E2F2,E2F3) [Reaction:R-HSA-9018017] RB1 binds and inhibits E2F1/2/3:DP1/2 complexes
(regulation)	[RegulationReference:9641568] Negative regulation by 'p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]' Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation

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