Reactome | RHOG GEFs activate RHOG

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RHOG GEFs activate RHOG Show undefined attributes

authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14
catalystActivity	[CatalystActivity:9014439] guanyl-nucleotide exchange factor activity of RHOG GEFs [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9014435] Orlic-Milacic, Marija, 2017-07-28
dbId	9014433
deleted	[Deleted:9768327] Deletion of instance: 194913
displayName	RHOG GEFs activate RHOG
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25
eventOf	[Pathway:R-HSA-9013408] RHOG GTPase cycle - Homo sapiens
followingEvent	[Reaction:R-HSA-9014434] RHOG GAPs stimulate RHOG GTPase activity - Homo sapiens [BlackBoxEvent:R-HSA-9014454] RHOG translocates to the ER membrane - Homo sapiens [Reaction:R-HSA-9014449] RHOG binds effectors at the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-9014438] RHOG:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9644217] Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins [LiteratureReference:9692967] Kalirin Dbl-homology guanine nucleotide exchange factor 1 domain initiates new axon outgrowths via RhoG-mediated mechanisms [LiteratureReference:9644429] Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins [LiteratureReference:9692946] P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils [LiteratureReference:5229003] Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2 [LiteratureReference:9679395] Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism [LiteratureReference:9692965] Ephexin4 and EphA2 mediate resistance to anoikis through RhoG and phosphatidylinositol 3-kinase [LiteratureReference:9679397] SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis [LiteratureReference:8980837] Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5 [LiteratureReference:9692903] RhoG signals in parallel with Rac1 and Cdc42 [LiteratureReference:9692974] The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth [LiteratureReference:9644570] Characterization of the activation of small GTPases by their GEFs on membranes using artificial membrane tethering [LiteratureReference:9692966] Guanine nucleotide exchange catalyzed by dbl oncogene product [LiteratureReference:9714742] TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	RHOG GEFs activate RHOG
orthologousEvent	[Reaction:R-GGA-9014433] RHOG GEFs activate RHOG - Gallus gallus [Reaction:R-XTR-9014433] RHOG GEFs activate RHOG - Xenopus tropicalis [Reaction:R-DRE-9014433] RHOG GEFs activate RHOG - Danio rerio [Reaction:R-SSC-9014433] RHOG GEFs activate RHOG - Sus scrofa [Reaction:R-BTA-9014433] RHOG GEFs activate RHOG - Bos taurus [Reaction:R-CFA-9014433] RHOG GEFs activate RHOG - Canis familiaris [Reaction:R-RNO-9014433] RHOG GEFs activate RHOG - Rattus norvegicus [Reaction:R-MMU-9014433] RHOG GEFs activate RHOG - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-9014437] RHOG:GTP [plasma membrane]
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9014433
summation	[Summation:9692977] The following guanine nucleotide exchange factors (GEFs) wer...

Referrals

(replacementInstances)	[Deleted:9768327] Deletion of instance: 194913
(precedingEvent)	[Reaction:R-HSA-9014434] RHOG GAPs stimulate RHOG GTPase activity [BlackBoxEvent:R-HSA-9014454] RHOG translocates to the ER membrane [Reaction:R-HSA-9014449] RHOG binds effectors at the plasma membrane
(hasEvent)	[Pathway:R-HSA-9013408] RHOG GTPase cycle

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