RHOG GEFs activate RHOG

Stable Identifier
R-HSA-9014433
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
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The following guanine nucleotide exchange factors (GEFs) were shown to bind RHOG and catalyze GDP to GTP exchange on RHOG, resulting in formation of the active RHOG:GTP complex:
ITSN1 (Jaiswal et al. 2013)
KALRN (May et al. 2002)
MCF2 (Zheng et al. 1995; Movilla and Bustelo 1999)
PREX1 (Damoulakis et al. 2014; Jaiswal et al. 2013)
TRIO (Blangy et al. 2000; Estrach et al. 2002; Peurois et al. 2017; Jaiswal et al. 2013; supported by interaction of TRIO with inactive RHOG mutant reported by Bagci et al. 2020)
VAV1 (Schuebel et al. 1998)
VAV3 (Movilla and Bustelo 1999)

The following GEFs, annotated as RHOG candidate GEFs, were shown to activate RHOG in some, but not all studies:
ARHGEF16 (Hiramoto Yamaki et al. 2010; Harada et al. 2011: RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)
ARHGEF26 (Ellerbroek et al. 2004: RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)
ARHGEF5 (Wang et al. 2009: weak RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)
MCF2L (Wennerberg et al. 2002; Jaiswal et al. 2013: RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)
VAV2 (Schuebel et al. 1998; Wennerberg et al. 2002; Jaiswal et al. 2013: RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)

The following GEFs were shown to either not act on RHOG or to not bind to inactive RHOG mutant in the high throughput screen by Bagci et al. 2020:
AKAP13 (Bagci et al. 2020)
ARHGEF1 (Bagci et al. 2020)
ARHGEF11 (Jaiswal et al. 2013; Bagci et al. 2020)
ARHGEF12 (Jaiswal et al. 2013; Bagci et al. 2020)
ARHGEF17 (Bagci et al. 2020)
ARHGEF2 (Bagci et al. 2020)
ARHGEF28 (Jaiswal et al. 2013)
ARHGEF3 (Arthur et al. 2002)
ARHGEF4 (Jaiswal et al. 2013)
ARHGEF40 (Bagci et al. 2020)
ARHGEF7 (Bagci et al. 2020)
ARHGEF9 (Jaiswal et al. 2013)
BCR (Bagci et al. 2020)
DNMBP (Jaiswal et al. 2013; Bagci et al. 2020)
DOCK6 (Bagci et al. 2020)
DOCK7 (Bagci et al. 2020)
DOCK8 (Bagci et al. 2020)
DOCK9 (Ruiz Lafuente et al. 2015; Bagci et al. 2020)
DOCK10 (Ruiz Lafuente et al. 2015)
DOCK11 (Ruiz Lafuente et al. 2015; Bagci et al. 2020)
ECT2 (Bagci et al. 2020)
FARP1 (Bagci et al. 2020)
NGEF (Bagci et al. 2020)
PLEKHG2 (Bagci et al. 2020)
PLEKHG3 (Bagci et al. 2020)
PLEKHG4 (Bagci et al. 2020)
PLEKHG5 (De Toledo et al. 2001)
SWAP70 (Bagci et al. 2020)
TIAM1 (Jaiswal et al. 2013; Bagci et al. 2020)

Literature References
PubMed ID Title Journal Year
11864571 The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth

Estrach, S, Schmidt, S, Diriong, S, Penna, A, Blangy, A, Fort, P, Debant, A

Curr. Biol. 2002
10523675 Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins

Movilla, N, Bustelo, XR

Mol. Cell. Biol. 1999
15133129 SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis

Ellerbroek, SM, Wennerberg, K, Arthur, WT, Dunty, JM, Bowman, DR, DeMali, KA, Der, C, Burridge, K

Mol. Biol. Cell 2004
21621533 Ephexin4 and EphA2 mediate resistance to anoikis through RhoG and phosphatidylinositol 3-kinase

Harada, K, Hiramoto-Yamaki, N, Negishi, M, Katoh, H

Exp. Cell Res. 2011
7476457 Guanine nucleotide exchange catalyzed by dbl oncogene product

Zheng, Y, Hart, MJ, Cerione, RA

Meth. Enzymol. 1995
12376551 RhoG signals in parallel with Rac1 and Cdc42

Wennerberg, K, Ellerbroek, SM, Liu, RY, Karnoub, AE, Burridge, K, Der, CJ

J. Biol. Chem. 2002
12177196 Kalirin Dbl-homology guanine nucleotide exchange factor 1 domain initiates new axon outgrowths via RhoG-mediated mechanisms

May, V, Schiller, MR, Eipper, BA, Mains, RE

J. Neurosci. 2002
20679435 Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism

Hiramoto-Yamaki, N, Takeuchi, S, Ueda, S, Harada, K, Fujimoto, S, Negishi, M, Katoh, H

J. Cell Biol. 2010
19713215 Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5

Wang, Z, Kumamoto, Y, Wang, P, Gan, X, Lehmann, D, Smrcka, AV, Cohn, L, Iwasaki, A, Li, L, Wu, D

J. Biol. Chem. 2009
23255595 Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins

Jaiswal, M, Dvorsky, R, Ahmadian, MR

J. Biol. Chem. 2013
28196833 Characterization of the activation of small GTPases by their GEFs on membranes using artificial membrane tethering

Peurois, F, Veyron, S, Ferrandez, Y, Ladid, I, Benabdi, S, Zeghouf, M, Peyroche, G, Cherfils, J

Biochem. J. 2017
9822605 Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

Schuebel, KE, Movilla, N, Rosa, JL, Bustelo, XR

EMBO J. 1998
10652265 TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG

Blangy, A, Vignal, E, Schmidt, S, Debant, A, Gauthier-Rouvière, C, Fort, P

J Cell Sci 2000
24659802 P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils

Damoulakis, G, Gambardella, L, Rossman, KL, Lawson, CD, Anderson, KE, Fukui, Y, Welch, HC, Der, CJ, Stephens, LR, Hawkins, PT

J. Cell. Sci. 2014
Participants
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Catalyst Activity

guanyl-nucleotide exchange factor activity of RHOG GEFs [cytosol]

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