Reactome | RHOG GEFs activate RHOG

RHOG GEFs activate RHOG

Stable Identifier

R-HSA-9014433

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The following guanine nucleotide exchange factors (GEFs) were shown to bind RHOG and catalyze GDP to GTP exchange on RHOG, resulting in formation of the active RHOG:GTP complex:
ITSN1 (Jaiswal et al. 2013)
KALRN (May et al. 2002)
MCF2 (Zheng et al. 1995; Movilla and Bustelo 1999)
PREX1 (Damoulakis et al. 2014; Jaiswal et al. 2013)
TRIO (Blangy et al. 2000; Estrach et al. 2002; Peurois et al. 2017; Jaiswal et al. 2013; supported by interaction of TRIO with inactive RHOG mutant reported by Bagci et al. 2020)
VAV1 (Schuebel et al. 1998)
VAV3 (Movilla and Bustelo 1999)

The following GEFs, annotated as RHOG candidate GEFs, were shown to activate RHOG in some, but not all studies:
ARHGEF16 (Hiramoto Yamaki et al. 2010; Harada et al. 2011: RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)
ARHGEF26 (Ellerbroek et al. 2004: RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)
ARHGEF5 (Wang et al. 2009: weak RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)
MCF2L (Wennerberg et al. 2002; Jaiswal et al. 2013: RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)
VAV2 (Schuebel et al. 1998; Wennerberg et al. 2002; Jaiswal et al. 2013: RHOG directed GEF activity; Bagci et al. 2020: no binding to inactive RHOG)

The following GEFs were shown to either not act on RHOG or to not bind to inactive RHOG mutant in the high throughput screen by Bagci et al. 2020:
AKAP13 (Bagci et al. 2020)
ARHGEF1 (Bagci et al. 2020)
ARHGEF11 (Jaiswal et al. 2013; Bagci et al. 2020)
ARHGEF12 (Jaiswal et al. 2013; Bagci et al. 2020)
ARHGEF17 (Bagci et al. 2020)
ARHGEF2 (Bagci et al. 2020)
ARHGEF28 (Jaiswal et al. 2013)
ARHGEF3 (Arthur et al. 2002)
ARHGEF4 (Jaiswal et al. 2013)
ARHGEF40 (Bagci et al. 2020)
ARHGEF7 (Bagci et al. 2020)
ARHGEF9 (Jaiswal et al. 2013)
BCR (Bagci et al. 2020)
DNMBP (Jaiswal et al. 2013; Bagci et al. 2020)
DOCK6 (Bagci et al. 2020)
DOCK7 (Bagci et al. 2020)
DOCK8 (Bagci et al. 2020)
DOCK9 (Ruiz Lafuente et al. 2015; Bagci et al. 2020)
DOCK10 (Ruiz Lafuente et al. 2015)
DOCK11 (Ruiz Lafuente et al. 2015; Bagci et al. 2020)
ECT2 (Bagci et al. 2020)
FARP1 (Bagci et al. 2020)
NGEF (Bagci et al. 2020)
PLEKHG2 (Bagci et al. 2020)
PLEKHG3 (Bagci et al. 2020)
PLEKHG4 (Bagci et al. 2020)
PLEKHG5 (De Toledo et al. 2001)
SWAP70 (Bagci et al. 2020)
TIAM1 (Jaiswal et al. 2013; Bagci et al. 2020)

Literature References

PubMed ID	Title	Journal	Year
10523675	Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins Bustelo, XR, Movilla, N	Mol. Cell. Biol.	1999
11864571	The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth Fort, P, Debant, A, Penna, A, Estrach, S, Schmidt, S, Blangy, A, Diriong, S	Curr. Biol.	2002
15133129	SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis Burridge, K, Dunty, JM, Ellerbroek, SM, Arthur, WT, Wennerberg, K, Bowman, DR, Der, C, DeMali, KA	Mol. Biol. Cell	2004
21621533	Ephexin4 and EphA2 mediate resistance to anoikis through RhoG and phosphatidylinositol 3-kinase Katoh, H, Hiramoto-Yamaki, N, Harada, K, Negishi, M	Exp. Cell Res.	2011
7476457	Guanine nucleotide exchange catalyzed by dbl oncogene product Cerione, RA, Hart, MJ, Zheng, Y	Meth. Enzymol.	1995
12376551	RhoG signals in parallel with Rac1 and Cdc42 Burridge, K, Karnoub, AE, Ellerbroek, SM, Liu, RY, Wennerberg, K, Der, CJ	J. Biol. Chem.	2002
12177196	Kalirin Dbl-homology guanine nucleotide exchange factor 1 domain initiates new axon outgrowths via RhoG-mediated mechanisms May, V, Eipper, BA, Schiller, MR, Mains, RE	J. Neurosci.	2002
20679435	Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism Katoh, H, Ueda, S, Hiramoto-Yamaki, N, Takeuchi, S, Harada, K, Fujimoto, S, Negishi, M	J. Cell Biol.	2010
19713215	Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5 Lehmann, D, Gan, X, Wang, P, Wang, Z, Li, L, Smrcka, AV, Iwasaki, A, Wu, D, Cohn, L, Kumamoto, Y	J. Biol. Chem.	2009
23255595	Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins Ahmadian, MR, Jaiswal, M, Dvorsky, R	J. Biol. Chem.	2013
28196833	Characterization of the activation of small GTPases by their GEFs on membranes using artificial membrane tethering Zeghouf, M, Ladid, I, Veyron, S, Ferrandez, Y, Cherfils, J, Peurois, F, Peyroche, G, Benabdi, S	Biochem. J.	2017
9822605	Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2 Bustelo, XR, Schuebel, KE, Rosa, JL, Movilla, N	EMBO J.	1998
10652265	TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG Blangy, A, Gauthier-Rouvière, C, Vignal, E, Debant, A, Schmidt, S, Fort, P	J Cell Sci	2000
24659802	P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils Fukui, Y, Damoulakis, G, Welch, HC, Anderson, KE, Rossman, KL, Hawkins, PT, Gambardella, L, Lawson, CD, Stephens, LR, Der, CJ	J. Cell. Sci.	2014