Reactome | RAC2 GDIs block activation of RAC2

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RAC2 GDIs block activation of RAC2 Show undefined attributes

authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14 [InstanceEdit:9695561] Rothfels, Karen, 2020-07-14
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9014292] Orlic-Milacic, Marija, 2017-07-27
dbId	9014293
deleted	[Deleted:9768324] Deletion of instance: 194854
displayName	RAC2 GDIs block activation of RAC2
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25
eventOf	[Pathway:R-HSA-9013404] RAC2 GTPase cycle - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-194478] ARHGDIA [cytosol] [Complex:R-HSA-9014401] RAC2:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9690966] Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase [LiteratureReference:196633] RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	RAC2 GDIs block activation of RAC2
orthologousEvent	[Reaction:R-DDI-9014293] RAC2 GDIs block activation of RAC2 - Dictyostelium discoideum [Reaction:R-GGA-9014293] RAC2 GDIs block activation of RAC2 - Gallus gallus [Reaction:R-XTR-9014293] RAC2 GDIs block activation of RAC2 - Xenopus tropicalis [Reaction:R-DRE-9014293] RAC2 GDIs block activation of RAC2 - Danio rerio [Reaction:R-SSC-9014293] RAC2 GDIs block activation of RAC2 - Sus scrofa [Reaction:R-BTA-9014293] RAC2 GDIs block activation of RAC2 - Bos taurus [Reaction:R-CFA-9014293] RAC2 GDIs block activation of RAC2 - Canis familiaris [Reaction:R-RNO-9014293] RAC2 GDIs block activation of RAC2 - Rattus norvegicus [Reaction:R-MMU-9014293] RAC2 GDIs block activation of RAC2 - Mus musculus
output	[Complex:R-HSA-9014414] ARHGDIA:RAC2:GDP [cytosol]
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9014293
summation	[Summation:9691575] ARHGDIA, a GDP dissociation inhibitor (GDI) binds to RAC2 an...

Referrals

(replacementInstances)	[Deleted:9768324] Deletion of instance: 194854
(hasEvent)	[Pathway:R-HSA-9013404] RAC2 GTPase cycle