Reactome | RAC2 GDIs block activation of RAC2

RAC2 GDIs block activation of RAC2

Stable Identifier

R-HSA-9014293

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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ARHGDIA, a GDP dissociation inhibitor (GDI) binds to RAC2 and inhibits its activation (Ando et al. 1992). ARHGDIG does not act on RAC2 (Adra et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
9113980	RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas Adra, CN, Manor, D, Ko, JL, Zhu, S, Horiuchi, T, Van Aelst, L, Cerione, RA, Lim, B	Proc Natl Acad Sci U S A	1997
1464587	Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase Ando, S, Kaibuchi, K, Sasaki, T, Hiraoka, K, Nishiyama, T, Mizuno, T, Asada, M, Nunoi, H, Matsuda, I, Matsuura, Y	J. Biol. Chem.	1992