RAC2 GDIs block activation of RAC2

Stable Identifier
R-HSA-9014293
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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ARHGDIA, a GDP dissociation inhibitor (GDI) binds to RAC2 and inhibits its activation (Ando et al. 1992). ARHGDIG does not act on RAC2 (Adra et al. 1997).

Literature References
PubMed ID Title Journal Year
1464587 Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase

Ando, S, Kaibuchi, K, Sasaki, T, Hiraoka, K, Nishiyama, T, Mizuno, T, Asada, M, Nunoi, H, Matsuda, I, Matsuura, Y

J. Biol. Chem. 1992
9113980 RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas

Adra, CN, Manor, D, Ko, JL, Zhu, S, Horiuchi, T, Van Aelst, L, Cerione, RA, Lim, B

Proc Natl Acad Sci U S A 1997
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