Reactome | RAC1 GTPase cycle

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RAC1 GTPase cycle Show undefined attributes

authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14 [InstanceEdit:9695561] Rothfels, Karen, 2020-07-14
created	[InstanceEdit:9013146] Orlic-Milacic, Marija, 2017-07-24
dbId	9013149
displayName	RAC1 GTPase cycle
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25
eventOf	[Pathway:R-HSA-9012999] RHO GTPase cycle - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9013143] RAC1 GEFs activate RAC1 - Homo sapiens [Reaction:R-HSA-9013144] RAC1 GAPs stimulate RAC1 GTPase activity - Homo sapiens [Reaction:R-HSA-9013147] RAC1 GDIs block activation of RAC1 - Homo sapiens [Reaction:R-HSA-9013145] RAC1 binds effectors at the plasma membrane - Homo sapiens [BlackBoxEvent:R-HSA-9691168] RAC1 translocates to the endoplasmic reticulum membrane - Homo sapiens [Reaction:R-HSA-9691174] RAC1 binds effectors at the ER membrane - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9694202] Potential roles of PP2A-Rac1 signaling axis in pancreatic ?-cell dysfunction under metabolic stress: Progress and Promise [LiteratureReference:9694201] Active RAC1 Promotes Tumorigenic Phenotypes and Therapy Resistance in Solid Tumors [LiteratureReference:9694208] The Role of Rac GTPase in Dendritic Spine Morphogenesis and Memory [LiteratureReference:9695181] RAC1 as a Therapeutic Target in Malignant Melanoma [LiteratureReference:9695191] Rac1 Signaling: From Intestinal Homeostasis to Colorectal Cancer Metastasis [LiteratureReference:9695194] The Regulatory Role of Rac1, a Small Molecular Weight GTPase, in the Development of Diabetic Retinopathy [LiteratureReference:9695197] RAC1 Takes the Lead in Solid Tumors [LiteratureReference:9695198] Compartmentalisation of RAC1 signalling [LiteratureReference:9695201] Crosstalk between Rac1-mediated actin regulation and ROS production [LiteratureReference:9695205] Epidermal activation of the small GTPase Rac1 in psoriasis pathogenesis [LiteratureReference:9695213] Tiam1/Vav2-Rac1 axis: A tug-of-war between islet function and dysfunction [LiteratureReference:9695212] Emerging roles of RAC1 in treating lung cancer patients [LiteratureReference:9695216] GEFs: Dual regulation of Rac1 signaling [LiteratureReference:9695220] The Ins and Outs of Small GTPase Rac1 in the Vasculature [LiteratureReference:9695226] Modulation of actin dynamics by Rac1 to target cognitive function [LiteratureReference:9695235] Rac1--a novel regulator of contraction-stimulated glucose uptake in skeletal muscle [LiteratureReference:9695229] Roles of Rac1 and Rac3 GTPases during the development of cortical and hippocampal GABAergic interneurons
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	RAC1 GTPase cycle
orthologousEvent	[Pathway:R-SCE-9013149] RAC1 GTPase cycle - Saccharomyces cerevisiae [Pathway:R-DDI-9013149] RAC1 GTPase cycle - Dictyostelium discoideum [Pathway:R-CEL-9013149] RAC1 GTPase cycle - Caenorhabditis elegans [Pathway:R-DME-9013149] RAC1 GTPase cycle - Drosophila melanogaster [Pathway:R-GGA-9013149] RAC1 GTPase cycle - Gallus gallus [Pathway:R-DRE-9013149] RAC1 GTPase cycle - Danio rerio [Pathway:R-SSC-9013149] RAC1 GTPase cycle - Sus scrofa [Pathway:R-CFA-9013149] RAC1 GTPase cycle - Canis familiaris [Pathway:R-RNO-9013149] RAC1 GTPase cycle - Rattus norvegicus [Pathway:R-MMU-9013149] RAC1 GTPase cycle - Mus musculus
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9013149
summation	[Summation:9694197] This pathway catalogues RAC1 guanine nucleotide exchange fac...
updateTrackers	[UpdateTracker:9864028] Update Tracker - [Pathway:9013149] RAC1 GTPase cycle - v88:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9864028] Update Tracker - [Pathway:9013149] RAC1 GTPase cycle - v88:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-9012999] RHO GTPase cycle

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