Reactome | RNASEL cleaves cellular ssRNA

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RNASEL cleaves cellular ssRNA Show undefined attributes

authored	[InstanceEdit:8983763] Shamovsky, Veronica, 2017-03-27
catalystActivity	[CatalystActivity:9009939] RNA endonuclease activity of RNASEL:2'-5' oligoadenylate [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9009930] Shamovsky, Veronica, 2017-06-23
dbId	9009936
displayName	RNASEL cleaves cellular ssRNA
edited	[InstanceEdit:9615065] Shamovsky, Veronica, 2018-07-31
eventOf	[Pathway:R-HSA-8983711] OAS antiviral response - Homo sapiens
input	[OtherEntity:R-ALL-170292] ssRNA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9009969] Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs [LiteratureReference:9614477] rRNA cleavage as an index of ppp(A2'p)nA activity in interferon-treated encephalomyocarditis virus-infected cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	RNASEL cleaves cellular ssRNA RNASEL cleaves cellular ssRNA to generate 5'-OH, 2'-3' cyclic phosphate RNA fragments
orthologousEvent	[BlackBoxEvent:R-GGA-9009936] RNASEL cleaves cellular ssRNA - Gallus gallus [BlackBoxEvent:R-SSC-9009936] RNASEL cleaves cellular ssRNA - Sus scrofa [BlackBoxEvent:R-BTA-9009936] RNASEL cleaves cellular ssRNA - Bos taurus [BlackBoxEvent:R-CFA-9009936] RNASEL cleaves cellular ssRNA - Canis familiaris [BlackBoxEvent:R-RNO-9009936] RNASEL cleaves cellular ssRNA - Rattus norvegicus [BlackBoxEvent:R-MMU-9009936] RNASEL cleaves cellular ssRNA - Mus musculus
output	[OtherEntity:R-ALL-9009945] RNA fragment with 2'-3' cyclic phosphate [cytosol]
precedingEvent	[Reaction:R-HSA-8985123] RNASEL binds 2'-5' oligoadenylate - Homo sapiens
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9615280] Silverman, Robert H, 2018-07-31
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9009936
summation	[Summation:9012239] Ribonuclease L (RNase L) is an ankyrin (ANK) repeat domain c...

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[Pathway:R-HSA-8983711] OAS antiviral response

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