Reactome | DDX5 binds ESR1:estrogen:TFF1 gene promoter

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DDX5 binds ESR1:estrogen:TFF1 gene promoter Show undefined attributes

authored	[InstanceEdit:9009527] Shamovsky, Veronica, 2017-06-20
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9009527] Shamovsky, Veronica, 2017-06-20
dbId	9009536
displayName	DDX5 binds ESR1:estrogen:TFF1 gene promoter
edited	[InstanceEdit:9028899] Rothfels, Karen, 2017-11-13
eventOf	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression - Homo sapiens
followingEvent	[Reaction:R-HSA-9023861] PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene - Homo sapiens [Reaction:R-HSA-9009533] TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3900136] DDX5 [nucleoplasm] [Complex:R-HSA-9009531] ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9009530] Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter [LiteratureReference:9023113] Transcriptional complexes engaged by apo-estrogen receptor-alpha isoforms have divergent outcomes [LiteratureReference:9023111] The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer [LiteratureReference:9023098] The DEAD-box p68/p72 proteins and the noncoding RNA steroid receptor activator SRA: eclectic regulators of disparate biological functions [LiteratureReference:9022229] Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications [LiteratureReference:9023094] Synergism between ERalpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 alpha-helical core and for a direct interaction between the N- and C-terminal domains
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	DDX5 binds ESR1:estrogen:TFF1 gene promoter
orthologousEvent	[Reaction:R-GGA-9009536] DDX5 binds ESR1:estrogen:TFF1 gene promoter - Gallus gallus [Reaction:R-XTR-9009536] DDX5 binds ESR1:estrogen:TFF1 gene promoter - Xenopus tropicalis [Reaction:R-DRE-9009536] DDX5 binds ESR1:estrogen:TFF1 gene promoter - Danio rerio [Reaction:R-SSC-9009536] DDX5 binds ESR1:estrogen:TFF1 gene promoter - Sus scrofa [Reaction:R-BTA-9009536] DDX5 binds ESR1:estrogen:TFF1 gene promoter - Bos taurus [Reaction:R-CFA-9009536] DDX5 binds ESR1:estrogen:TFF1 gene promoter - Canis familiaris [Reaction:R-RNO-9009536] DDX5 binds ESR1:estrogen:TFF1 gene promoter - Rattus norvegicus [Reaction:R-MMU-9009536] DDX5 binds ESR1:estrogen:TFF1 gene promoter - Mus musculus
output	[Complex:R-HSA-9009528] ESR1:estrogen:TFF1 gene:FOXA1:GATA3:DDX5 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9009541] ESR1 binds to TFF1 gene promoter - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9038169] Magnani, Luca, 2018-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9009536
summation	[Summation:9023792] DDX5, also known as p68, is a putative RNA helicase that is ...

Referrals

(precedingEvent)	[Reaction:R-HSA-9023861] PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene [Reaction:R-HSA-9009533] TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter
(hasEvent)	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression

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