DDX5 binds ESR1:estrogen:TFF1 gene promoter

Stable Identifier
R-HSA-9009536
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

DDX5, also known as p68, is a putative RNA helicase that is implicated in estrogen-responsive signaling (Métivier et al, 2003; Métivier et al, 2004; Wortham et al, 2009; reviewed in Caretti et al, 2007; Arnal et al, 2017). DDX5 is recruited to the TFF1 promoter early during transcriptional activation and modulates the activity of the AF1 activator region of the estrogen receptor (Métivier et al, 2001; Métivier et al, 2003, Métivier et al, 2004).

Literature References
PubMed ID Title Journal Year
19718048 The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer

Wortham, NC, Ahamed, E, Nicol, SM, Thomas, RS, Periyasamy, M, Jiang, J, Ochocka, AM, Shousha, S, Huson, L, Bray, SE, Coombes, RC, Ali, S, Fuller-Pace, FV

Oncogene 2009
11682626 Synergism between ERalpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 alpha-helical core and for a direct interaction between the N- and C-terminal domains

Métivier, R, Penot, G, Flouriot, G, Pakdel, F

Mol. Endocrinol. 2001
28539435 Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications

Arnal, JF, Lenfant, F, Métivier, R, Flouriot, G, Henrion, D, Adlanmerini, M, Fontaine, C, Gourdy, P, Chambon, P, Katzenellenbogen, B, Katzenellenbogen, J

Physiol. Rev. 2017
17495528 The DEAD-box p68/p72 proteins and the noncoding RNA steroid receptor activator SRA: eclectic regulators of disparate biological functions

Caretti, G, Lei, EP, Sartorelli, V

Cell Cycle 2007
14675539 Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

Métivier, R, Penot, G, Hübner, MR, Reid, G, Brand, H, Kos, M, Gannon, F

Cell 2003
15343269 Transcriptional complexes engaged by apo-estrogen receptor-alpha isoforms have divergent outcomes

Métivier, R, Penot, G, Carmouche, RP, Hübner, MR, Reid, G, Denger, S, Manu, D, Brand, H, Kos, M, Benes, V, Gannon, F

EMBO J. 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created