DDX5 binds ESR1:estrogen:TFF1 gene promoter

Stable Identifier
Reaction [binding]
Homo sapiens
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DDX5, also known as p68, is a putative RNA helicase that is implicated in estrogen-responsive signaling (Métivier et al, 2003; Métivier et al, 2004; Wortham et al, 2009; reviewed in Caretti et al, 2007; Arnal et al, 2017). DDX5 is recruited to the TFF1 promoter early during transcriptional activation and modulates the activity of the AF1 activator region of the estrogen receptor (Métivier et al, 2001; Métivier et al, 2003, Métivier et al, 2004).
Literature References
PubMed ID Title Journal Year
11682626 Synergism between ERalpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 alpha-helical core and for a direct interaction between the N- and C-terminal domains

Pakdel, F, Flouriot, G, Métivier, R, Penot, G

Mol. Endocrinol. 2001
19718048 The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer

Fuller-Pace, FV, Periyasamy, M, Wortham, NC, Nicol, SM, Shousha, S, Ali, S, Huson, L, Bray, SE, Ahamed, E, Thomas, RS, Ochocka, AM, Coombes, RC, Jiang, J

Oncogene 2009
28539435 Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications

Katzenellenbogen, B, Chambon, P, Flouriot, G, Métivier, R, Henrion, D, Katzenellenbogen, J, Arnal, JF, Lenfant, F, Gourdy, P, Fontaine, C, Adlanmerini, M

Physiol. Rev. 2017
17495528 The DEAD-box p68/p72 proteins and the noncoding RNA steroid receptor activator SRA: eclectic regulators of disparate biological functions

Sartorelli, V, Lei, EP, Caretti, G

Cell Cycle 2007
14675539 Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

Reid, G, Métivier, R, Brand, H, Kos, M, Penot, G, Gannon, F, Hübner, MR

Cell 2003
15343269 Transcriptional complexes engaged by apo-estrogen receptor-alpha isoforms have divergent outcomes

Reid, G, Métivier, R, Brand, H, Kos, M, Penot, G, Gannon, F, Denger, S, Manu, D, Carmouche, RP, Benes, V, Hübner, MR

EMBO J. 2004
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