Reactome | DDX5 binds ESR1:estrogen:TFF1 gene promoter

DDX5 binds ESR1:estrogen:TFF1 gene promoter

Stable Identifier

R-HSA-9009536

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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DDX5 binds ESR1:estrogen:TFF1 gene promoter

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DDX5, also known as p68, is a putative RNA helicase that is implicated in estrogen-responsive signaling (Métivier et al, 2003; Métivier et al, 2004; Wortham et al, 2009; reviewed in Caretti et al, 2007; Arnal et al, 2017). DDX5 is recruited to the TFF1 promoter early during transcriptional activation and modulates the activity of the AF1 activator region of the estrogen receptor (Métivier et al, 2001; Métivier et al, 2003, Métivier et al, 2004).

Literature References

PubMed ID	Title	Journal	Year
11682626	Synergism between ERalpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 alpha-helical core and for a direct interaction between the N- and C-terminal domains Métivier, R, Penot, G, Flouriot, G, Pakdel, F	Mol. Endocrinol.	2001
19718048	The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer Wortham, NC, Ahamed, E, Nicol, SM, Thomas, RS, Periyasamy, M, Jiang, J, Ochocka, AM, Shousha, S, Huson, L, Bray, SE, Coombes, RC, Ali, S, Fuller-Pace, FV	Oncogene	2009
28539435	Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications Arnal, JF, Lenfant, F, Métivier, R, Flouriot, G, Henrion, D, Adlanmerini, M, Fontaine, C, Gourdy, P, Chambon, P, Katzenellenbogen, B, Katzenellenbogen, J	Physiol. Rev.	2017
17495528	The DEAD-box p68/p72 proteins and the noncoding RNA steroid receptor activator SRA: eclectic regulators of disparate biological functions Caretti, G, Lei, EP, Sartorelli, V	Cell Cycle	2007
14675539	Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter Métivier, R, Penot, G, Hübner, MR, Reid, G, Brand, H, Kos, M, Gannon, F	Cell	2003
15343269	Transcriptional complexes engaged by apo-estrogen receptor-alpha isoforms have divergent outcomes Métivier, R, Penot, G, Carmouche, RP, Hübner, MR, Reid, G, Denger, S, Manu, D, Brand, H, Kos, M, Benes, V, Gannon, F	EMBO J.	2004