Reactome | BAX gene expression is stimulated by RUNX2

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BAX gene expression is stimulated by RUNX2 Show undefined attributes

authored	[InstanceEdit:9008829] Orlic-Milacic, Marija, 2017-06-13
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9008829] Orlic-Milacic, Marija, 2017-06-13
dbId	9008839
displayName	BAX gene expression is stimulated by RUNX2
edited	[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3700977] BAX gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9008841] Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio [LiteratureReference:9008840] Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents [LiteratureReference:9008835] Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BAX gene expression is stimulated by RUNX2
output	[EntityWithAccessionedSequence:R-HSA-139916] BAX [cytosol]
precedingEvent	[Reaction:R-HSA-9008832] RUNX2 binds BAX gene promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-9008864] Positive gene expression regulation by 'RUNX2:CBFB:BAX gene [nucleoplasm]'
regulationReference	[RegulationReference:9642441] Positive gene expression regulation by 'RUNX2:CBFB:BAX gene [nucleoplasm]' Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9008839
summation	[Summation:9008863] BAX gene transcription is directly stimulated by binding of ...

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(hasEvent)

[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2

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