BAX gene expression is stimulated by RUNX2

Stable Identifier
R-HSA-9008839
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

BAX gene transcription is directly stimulated by binding of RUNX2, presumably in complex with CBFB, to RUNX2 response elements in the BAX promoter (Eliseev et al. 2008, Goloudina, Tanoue et al. 2012, Goloudina, Mazur et al. 2012).

Literature References
PubMed ID Title Journal Year
18223689 Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis

Rosier, RN, Zuscik, MJ, Drissi, MH, Dong, YF, Schwarz, EM, Sampson, E, Eliseev, RA, O'Keefe, RJ

Oncogene 2008
22065775 Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents

Hammann, A, Garrido, C, Goloudina, AR, Bulavin, DV, Appella, E, Tanoue, K, le Guezennec, X, Demidov, ON, Fourmaux, E, Mazur, SJ

Proc. Natl. Acad. Sci. U.S.A. 2012
22544321 Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio

Garrido, C, Goloudina, AR, Appella, E, Demidov, ON, Mazur, SJ

Cell Cycle 2012
Participants
Participates
This event is regulated
Authored
Reviewed
Created
Cite Us!