Reactome | Negative regulation by 'E2F6:(TFDP1,TFDP2):RRM2 gene [nucleoplasm]'

Schema > NegativeRegulation > Entries

activeUnit	[Complex:R-HSA-8954085] E2F6:(TFDP1,TFDP2) [nucleoplasm] - Homo sapiens
created	[InstanceEdit:9007594] Orlic-Milacic, Marija, 2017-05-31
dbId	9007593
displayName	Negative regulation by 'E2F6:(TFDP1,TFDP2):RRM2 gene [nucleoplasm]'
modified	[InstanceEdit:9608020] Wu, G, 2018-05-08
regulatedEntity	[BlackBoxEvent:R-HSA-8961982] RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 - Homo sapiens
regulator	[Complex:R-HSA-9007590] E2F6:(TFDP1,TFDP2):RRM2 gene [nucleoplasm]
schemaClass	NegativeRegulation
stId	R-HSA-9007593

(regulation)	[RegulationReference:9641521] Negative regulation by 'E2F6:(TFDP1,TFDP2):RRM2 gene [nucleoplasm]' Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription
(regulatedBy)	[BlackBoxEvent:R-HSA-8961982] RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6

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