Reactome | GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol

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GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol Show undefined attributes

authored	[InstanceEdit:113845] D'Eustachio, P, 2004-06-23 11:10:00
catalystActivity	[CatalystActivity:8981550] D-glucose transmembrane transporter activity of GLUT4 / SLC2A4 tetramer [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:8981563] D'Eustachio, Peter, 2017-03-10
crossReference	[DatabaseIdentifier:12667692] RHEA:60376
dbId	8981570
displayName	GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol
edited	[InstanceEdit:113845] D'Eustachio, P, 2004-06-23 11:10:00
eventOf	[Pathway:R-HSA-189200] Cellular hexose transport - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:6808140] D-glucose transmembrane transport
input	[SimpleEntity:R-ALL-70115] Glc [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:70143] Regulated transport of the glucose transporter GLUT4 [LiteratureReference:428777] Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects [LiteratureReference:70388] Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues. [LiteratureReference:428811] Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol
negativePrecedingEvent	[NegativePrecedingEvent:9963441] Futile Cycle: GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region [NegativePrecedingEvent:9963445] Futile Cycle: SLC50A1 transports Glc from cytosol to extracellular region
orthologousEvent	[Reaction:R-PFA-8981570] GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol - Plasmodium falciparum [Reaction:R-SCE-8981570] GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol - Saccharomyces cerevisiae [Reaction:R-DDI-8981570] GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol - Dictyostelium discoideum [Reaction:R-CEL-8981570] GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol - Caenorhabditis elegans [Reaction:R-DME-8981570] GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol - Drosophila melanogaster [Reaction:R-GGA-8981570] GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol - Gallus gallus [Reaction:R-XTR-8981570] GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol - Xenopus tropicalis [Reaction:R-SSC-8981570] GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol - Sus scrofa [Reaction:R-BTA-8981570] GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol - Bos taurus [Reaction:R-CFA-8981570] GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol - Canis familiaris [Reaction:R-RNO-8981570] GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol - Rattus norvegicus [Reaction:R-MMU-8981570] GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol - Mus musculus
output	[SimpleEntity:R-ALL-70113] Glc [cytosol]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:433651] He, L, 2009-08-24
revised	[InstanceEdit:450087] D'Eustachio, P, 2009-12-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8981570
summation	[Summation:8981559] Tetrameric GLUT4, the SLC2A4 gene product, associated with t...

Referrals

(hasEvent)	[Pathway:R-HSA-189200] Cellular hexose transport
(precedingEvent)	[NegativePrecedingEvent:9963464] Futile Cycle: GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol [NegativePrecedingEvent:9963437] Futile Cycle: GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol

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