Reactome | GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol

GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol

Stable Identifier

R-HSA-8981570

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

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GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol

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Tetrameric GLUT4, the SLC2A4 gene product, associated with the plasma membrane, mediates the facilitated diffusion of glucose (Glc) into cells. GLUT4 is found in heart, skeletal muscle, brain and adipose tissue. GLUT4 molecules are translocated from an intracellular store to the cell surface in response to increased insulin levels, increasing glucose transport 10-20-fold (Bryant et al. 2002; Fukumoto et al. 1989). Defects in SLC2A4 may be a cause of non-insulin-dependent diabetes mellitus (NIDDM) (Kusari et al. 1991; Choi et al. 1991).

Literature References

PubMed ID	Title	Journal	Year
1756912	Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects Flier, JS, Buse, JB, Choi, WH, Morgan, R, Moller, DE, O'Rahilly, S, Rees, A	Diabetes	1991
11994746	Regulated transport of the glucose transporter GLUT4. James, DE, Bryant, NJ, Govers, R	Nat Rev Mol Cell Biol	2002
1918382	Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus Buse, JB, Verma, US, Olefsky, JM, Henry, RR, Kusari, J	J Clin Invest	1991
2656669	Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues. Bell, GI, Pilch, PF, Seino, S, Kayano, T, Buse, JB, Fukumoto, H	J Biol Chem	1989