GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol

Stable Identifier
R-HSA-8981570
Type
Reaction [transition]
Species
Homo sapiens
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Tetrameric GLUT4, the SLC2A4 gene product, associated with the plasma membrane, mediates the facilitated diffusion of glucose (Glc) into cells. GLUT4 is found in heart, skeletal muscle, brain and adipose tissue. GLUT4 molecules are translocated from an intracellular store to the cell surface in response to increased insulin levels, increasing glucose transport 10-20-fold (Bryant et al. 2002; Fukumoto et al. 1989). Defects in SLC2A4 may be a cause of non-insulin-dependent diabetes mellitus (NIDDM) (Kusari et al. 1991; Choi et al. 1991).

Literature References
PubMed ID Title Journal Year
11994746 Regulated transport of the glucose transporter GLUT4.

Bryant, NJ, Govers, R, James, DE

Nat Rev Mol Cell Biol 2002
1756912 Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects

Choi, WH, O'Rahilly, S, Buse, JB, Rees, A, Morgan, R, Flier, JS, Moller, DE

Diabetes 1991
1918382 Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus

Kusari, J, Verma, US, Buse, JB, Henry, RR, Olefsky, JM

J Clin Invest 1991
2656669 Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues.

Fukumoto, H, Kayano, T, Buse, JB, Pilch, PF, Bell, GI, Seino, S

J Biol Chem 1989
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Catalyst Activity
Title
D-glucose transmembrane transporter activity of GLUT4 / SLC2A4 tetramer [plasma membrane]
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