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Schema
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Reaction
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Entries
PGP:Mg2+ dimer hydrolyses G3P to glycerol
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authored
[InstanceEdit:8955795] Jassal, Bijay, 2017-01-13
catalystActivity
[CatalystActivity:8955800] sn-glycerol 3-phosphatase activity of PGP:Mg2+ dimer [cytosol]
catalystActivityReference
[CatalystActivityReference:9935658] glycerol-3-phosphatase activity of PGP:Mg2+ dimer [cytosol] Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic ?-cells and hepatocytes
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:8955795] Jassal, Bijay, 2017-01-13
crossReference
[DatabaseIdentifier:12668414] RHEA:66373
[DatabaseIdentifier:9935669] RHEA:66373
dbId
8955794
deleted
[Deleted:9935679] Deletion of instance: 8955775
displayName
PGP:Mg2+ dimer hydrolyses G3P to glycerol
edited
[InstanceEdit:8955795] Jassal, Bijay, 2017-01-13
eventOf
[Pathway:R-HSA-1483206] Glycerophospholipid biosynthesis - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:15779] glycerol biosynthetic process
input
[SimpleEntity:R-ALL-76114] G3P [cytosol]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9935672] Glycerol-3-phosphate phosphatase operates a glycerol shunt in pancreatic ?-cells that controls insulin secretion and metabolic stress
[LiteratureReference:9935676] Hepatic glycerol shunt and glycerol-3-phosphate phosphatase control liver metabolism and glucodetoxification under hyperglycemia
[LiteratureReference:8955768] Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic ?-cells and hepatocytes
[LiteratureReference:9935675] Essential role of germ cell glycerol-3-phosphate phosphatase for sperm health, oxidative stress control and male fertility in mice
[LiteratureReference:9935673] Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities
maxDepth
1
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
PGP:Mg2+ dimer hydrolyses G3P to glycerol
sn-glycerol 3-phosphate + H2O => glycerol + phosphate
orthologousEvent
[Reaction:R-CEL-8955794] PGP:Mg2+ dimer hydrolyses G3P to glycerol - Caenorhabditis elegans
[Reaction:R-DME-8955794] PGP:Mg2+ dimer hydrolyses G3P to glycerol - Drosophila melanogaster
[Reaction:R-GGA-8955794] PGP:Mg2+ dimer hydrolyses G3P to glycerol - Gallus gallus
[Reaction:R-XTR-8955794] PGP:Mg2+ dimer hydrolyses G3P to glycerol - Xenopus tropicalis
[Reaction:R-DRE-8955794] PGP:Mg2+ dimer hydrolyses G3P to glycerol - Danio rerio
[Reaction:R-SSC-8955794] PGP:Mg2+ dimer hydrolyses G3P to glycerol - Sus scrofa
[Reaction:R-BTA-8955794] PGP:Mg2+ dimer hydrolyses G3P to glycerol - Bos taurus
[Reaction:R-CFA-8955794] PGP:Mg2+ dimer hydrolyses G3P to glycerol - Canis familiaris
[Reaction:R-RNO-8955794] PGP:Mg2+ dimer hydrolyses G3P to glycerol - Rattus norvegicus
[Reaction:R-MMU-8955794] PGP:Mg2+ dimer hydrolyses G3P to glycerol - Mus musculus
output
[SimpleEntity:R-ALL-76116] Glycerol [cytosol]
[SimpleEntity:R-ALL-29372] Pi [cytosol]
previousReviewStatus
[ReviewStatus:9821385] four stars
releaseDate
2017-03-27
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8959643] D'Eustachio, Peter, 2017-01-30
[InstanceEdit:9939401] Hill, David P, 2025-02-26
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8955794
summation
[Summation:8955799] Cytosolic PGP (Glycerol-3-phosphate phosphatase) catalyzes t...
updateTrackers
[UpdateTracker:9939843] Update Tracker - [Reaction:8955794] PGP:Mg2+ dimer hydrolyses G3P to glycerol - v92:[add_removeInput, modifyText, removeLiteratureReference]
Referrals
(updatedInstance)
[UpdateTracker:9939843] Update Tracker - [Reaction:8955794] PGP:Mg2+ dimer hydrolyses G3P to glycerol - v92:[add_removeInput, modifyText, removeLiteratureReference]
(replacementInstances)
[Deleted:9935679] Deletion of instance: 8955775
(hasEvent)
[Pathway:R-HSA-1483206] Glycerophospholipid biosynthesis
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