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Schema
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Reaction
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Entries
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
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authored
[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:8955288] Rothfels, Karen, 2017-01-10
dbId
8955289
displayName
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
edited
[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
eventOf
[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
followingEvent
[Reaction:R-HSA-8956200] MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex - Homo sapiens
[Reaction:R-HSA-8952630] NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex - Homo sapiens
[Reaction:R-HSA-8952625] NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex - Homo sapiens
[Reaction:R-HSA-8952039] NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex - Homo sapiens
[Reaction:R-HSA-8952620] NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex - Homo sapiens
input
[Complex:R-HSA-8955646] COMMDs:CCDC22 [cytosol]
[Complex:R-HSA-8955224] CRL E3 ubiquitin ligase:CAND1 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8955456] COMMD proteins, a novel family of structural and functional homologs of MURR1
[LiteratureReference:8955457] COMMD proteins: COMMing to the scene
[LiteratureReference:8955461] COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase
[LiteratureReference:8955459] COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding
[LiteratureReference:8955442] CCDC22 deficiency in humans blunts activation of proinflammatory NF-?B signaling
[LiteratureReference:8955690] COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A
maxDepth
1
modified
[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
orthologousEvent
[Reaction:R-DDI-8955289] COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes - Dictyostelium discoideum
[Reaction:R-XTR-8955289] COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes - Xenopus tropicalis
[Reaction:R-DRE-8955289] COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes - Danio rerio
[Reaction:R-SSC-8955289] COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes - Sus scrofa
[Reaction:R-BTA-8955289] COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes - Bos taurus
[Reaction:R-CFA-8955289] COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes - Canis familiaris
[Reaction:R-RNO-8955289] COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes - Rattus norvegicus
[Reaction:R-MMU-8955289] COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes - Mus musculus
output
[EntityWithAccessionedSequence:R-HSA-5691146] CAND1 [cytosol]
[DefinedSet:R-HSA-8955229] CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol]
precedingEvent
[Reaction:R-HSA-8955241] CAND1 binds cytosolic CRL E3 ubiquitin ligases - Homo sapiens
releaseDate
2017-03-27
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8979124] Pick, Elah, 2017-02-21
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8955289
summation
[Summation:8955478] COMMD1 is a member of a family of 10 copper metabolism MURR1...
Referrals
(precedingEvent)
[Reaction:R-HSA-8956200] MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex
[Reaction:R-HSA-8952630] NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex
[Reaction:R-HSA-8952625] NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex
[Reaction:R-HSA-8952039] NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex
[Reaction:R-HSA-8952620] NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex
[NegativePrecedingEvent:9767177] Futile Cycle: COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
(hasEvent)
[Pathway:R-HSA-8951664] Neddylation
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