Reactome | NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex

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NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex Show undefined attributes

authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8952627] Rothfels, Karen, 2016-12-15
dbId	8952625
displayName	NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
eventOf	[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
followingEvent	[Reaction:R-HSA-8952626] AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex - Homo sapiens
input	[Complex:R-HSA-8955228] CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] [CandidateSet:R-HSA-8952547] DCUN1D1,2,4,5 [cytosol] [Complex:R-HSA-4419896] NEDD8-AcM-UBE2M [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8952185] E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification [LiteratureReference:8952007] Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes [LiteratureReference:8952191] SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation [LiteratureReference:8952178] Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation [LiteratureReference:8952208] The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes [LiteratureReference:8955142] DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase [LiteratureReference:8952170] Characterization of the mammalian family of DCN-type NEDD8 E3 ligases [LiteratureReference:8952186] N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex [LiteratureReference:8955468] SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1) [LiteratureReference:5690803] Protein neddylation: beyond cullin-RING ligases [LiteratureReference:8955180] The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions [LiteratureReference:9766094] Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis [LiteratureReference:8953189] Cullin E3 ligases and their rewiring by viral factors
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex
orthologousEvent	[Reaction:R-DDI-8952625] NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex - Dictyostelium discoideum [Reaction:R-DME-8952625] NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex - Drosophila melanogaster [Reaction:R-DRE-8952625] NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex - Danio rerio [Reaction:R-BTA-8952625] NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex - Bos taurus [Reaction:R-RNO-8952625] NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex - Rattus norvegicus [Reaction:R-MMU-8952625] NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex - Mus musculus
output	[Complex:R-HSA-8952574] NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol]
precedingEvent	[Reaction:R-HSA-8951661] Transfer of NEDD8 to AcM-UBE2M - Homo sapiens [Reaction:R-HSA-8955289] COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes - Homo sapiens
releaseDate	2022-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9768153] Somers, Julia, 2022-03-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8952625
summation	[Summation:8955260] UBE2M is the E2 ubiquitin ligase for CRL complexes containin...

Referrals

(hasEvent)	[Pathway:R-HSA-8951664] Neddylation
(precedingEvent)	[Reaction:R-HSA-8952626] AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex

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