Reactome | E2F7 forms homodimers

Schema > Reaction > Entries

E2F7 forms homodimers Show undefined attributes

authored	[InstanceEdit:8953036] Orlic-Milacic, Marija, 2016-12-21
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8952999] Orlic-Milacic, Marija, 2016-12-21
dbId	8952996
displayName	E2F7 forms homodimers
edited	[InstanceEdit:8953960] Orlic-Milacic, Marija, 2017-01-03 [InstanceEdit:8959605] Orlic-Milacic, Marija, 2017-01-27
eventOf	[Pathway:R-HSA-6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest - Homo sapiens
followingEvent	[Reaction:R-HSA-6798347] E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-6798305] E2F7 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8952995] E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains [LiteratureReference:8953005] E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes [LiteratureReference:8953023] Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	E2F7 forms homodimers
orthologousEvent	[Reaction:R-DRE-8952996] E2F7 forms homodimers - Danio rerio [Reaction:R-CEL-8952996] E2F7 forms homodimers - Caenorhabditis elegans [Reaction:R-GGA-8952996] E2F7 forms homodimers - Gallus gallus [Reaction:R-XTR-8952996] E2F7 forms homodimers - Xenopus tropicalis [Reaction:R-SSC-8952996] E2F7 forms homodimers - Sus scrofa [Reaction:R-BTA-8952996] E2F7 forms homodimers - Bos taurus [Reaction:R-CFA-8952996] E2F7 forms homodimers - Canis familiaris [Reaction:R-RNO-8952996] E2F7 forms homodimers - Rattus norvegicus [Reaction:R-MMU-8952996] E2F7 forms homodimers - Mus musculus
output	[Complex:R-HSA-8953000] E2F7 homodimer [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-6798299] TP53 stimulates E2F7 expression - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8953962] Di Stefano, Luisa, 2017-01-03 [InstanceEdit:8959604] Westendorp, Bart, 2017-01-24 [InstanceEdit:8959602] de Bruin, Alain, 2017-01-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8952996
summation	[Summation:8953011] E2F7 forms homodimers (Di Stefano et al. 2003, Logan et al. ...

Referrals

(precedingEvent)	[Reaction:R-HSA-6798347] E2F7 and E2F8 homo- and heterodimers bind the E2F1 gene promoter
(hasEvent)	[Pathway:R-HSA-6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest