Reactome | E2F7 forms homodimers

E2F7 forms homodimers

Stable Identifier

R-HSA-8952996

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
        
        E2F7 forms homodimers (Homo sapiens)

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E2F7 forms homodimers (Di Stefano et al. 2003, Logan et al. 2004). While E2F7 also forms heterodimers with E2F8, co-immunoprecipitation experiments suggest that E2F7 has higher affinity for itself than for E2F8 (Li et al. 2008)

Literature References

PubMed ID	Title	Journal	Year
15133492	E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains Reilly, C, Delavaine, L, Graham, A, Wilson, J, Logan, N, Brummelkamp, TR, La Thangue, NB, Bernards, R, Hijmans, EM	Oncogene	2004
18194653	Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development Siddiqui, H, Ran, C, Li, J, de Bruin, A, Chen, HZ, Li, E, Kornacker, K, Pandit, SK, Khanizadeh, M, Liu, CG, Gordon, F, Cleghorn, W, Leone, G, Comstock, G, Weinstein, M	Dev. Cell	2008
14633988	E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes Helin, K, Jensen, MR, Di Stefano, L	EMBO J.	2003