Reactome | Transfer of NEDD8 to AcM-UBE2F

Schema > Reaction > Entries

Transfer of NEDD8 to AcM-UBE2F Show undefined attributes

authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
catalystActivity	[CatalystActivity:8951765] NEDD8 transferase activity of AcM-UBE2F:NEDD8-UBA3:NAE1:NEDD8 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8951763] Rothfels, Karen, 2016-12-09
dbId	8951764
displayName	Transfer of NEDD8 to AcM-UBE2F
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
eventOf	[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
followingEvent	[Reaction:R-HSA-8952039] NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex - Homo sapiens
input	[Complex:R-HSA-8951762] AcM-UBE2F:NEDD8-UBA3:NAE1:NEDD8 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8951606] The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1 [LiteratureReference:8951615] A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8 [LiteratureReference:8951603] Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1 [LiteratureReference:8951620] Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Transfer of NEDD8 to AcM-UBE2F
output	[Complex:R-HSA-8951756] NEDD8-AcM-UBE2F [cytosol] [Complex:R-HSA-8951646] NEDD8-UBA3:NAE1 [cytosol]
precedingEvent	[Reaction:R-HSA-8951766] Doubly neddylated UBA3:NAE1 binds AcM-UBE2F - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8979124] Pick, Elah, 2017-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8951764
summation	[Summation:8952038] UBA3:NAE1 transfers NEDD8 to the catalytic cysteine residue ...

Referrals

(hasEvent)	[Pathway:R-HSA-8951664] Neddylation
(precedingEvent)	[NegativePrecedingEvent:9767194] Futile Cycle: Transfer of NEDD8 to AcM-UBE2F [Reaction:R-HSA-8952039] NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex

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