Reactome | Transfer of NEDD8 to AcM-UBE2F

Transfer of NEDD8 to AcM-UBE2F

Stable Identifier

R-HSA-8951764

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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UBA3:NAE1 transfers NEDD8 to the catalytic cysteine residue of UBE2F. Because two of the three E1-E2 interaction interfaces are created by conformational states present in the doubly-NEDDylated NAE1, transfer of NEDD8 to UBE2M is thought to weaken the interaction between UBA3:NAE1 and UBE2F, contributing to UBE2F release (Walden et al, 2003; Huang et al, 2004; Hunag et al, 2005; Huang et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
14690597	The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1 Miller, DW, Huang, DT, Howard, RJ, Schulman, BA, Holton, JM, Minor, DL, Walden, H, Podgorski, MS	Mol. Cell	2003
17220875	Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity Huang, DT, Ohi, MD, Hunt, HW, Schulman, BA, Holton, JM, Zhuang, M	Nature	2007
15694336	Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1 Huang, DT, Schulman, BA, Holton, JM, Paydar, A, Waddell, MB, Zhuang, M	Mol. Cell	2005
15361859	A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8 Miller, DW, Huang, DT, Cassell, R, Schulman, BA, Roussel, MF, Holton, JM, Mathew, R	Nat. Struct. Mol. Biol.	2004