Reactome | GUCY2C trimer binds sta1

Schema > Reaction > Entries

GUCY2C trimer binds sta1 Show undefined attributes

authored	[InstanceEdit:8936355] Jassal, Bijay, 2016-08-18
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8936355] Jassal, Bijay, 2016-08-18
crossReference	[DatabaseIdentifier:12020819] Mondo:0002269
dbId	8936356
disease	[Disease:9699213] gastroenteritis
displayName	GUCY2C trimer binds sta1
edited	[InstanceEdit:8936355] Jassal, Bijay, 2016-08-18
eventOf	[Pathway:R-HSA-8942233] Intestinal infectious diseases - Homo sapiens
input	[Complex:R-HSA-8936213] GUCY2C trimer [plasma membrane] [EntityWithAccessionedSequence:R-ECO-8936232] Sta1 [extracellular region]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:8936199] Biochemical characterization of the intracellular domain of the human guanylyl cyclase C receptor provides evidence for a catalytically active homotrimer [LiteratureReference:8936352] Receptor guanylyl cyclase C (GC-C): regulation and signal transduction [LiteratureReference:8936358] Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36 [LiteratureReference:8936360] Toxin mediated diarrhea in the 21 century: the pathophysiology of intestinal ion transport in the course of ETEC, V. cholerae and rotavirus infection [LiteratureReference:8936374] A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GUCY2C trimer binds sta1
output	[Complex:R-HSA-8936363] GUCY2C trimer:sta1 [plasma membrane]
regulatedBy	[NegativeRegulation:R-HSA-8936369] Negative regulation by 'PDZD3 [plasma membrane]'
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8942222] D'Eustachio, Peter, 2016-10-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8936356
summation	[Summation:8936359] Heat-stable enterotoxin receptor (GUCY2C, STAR) is the recep...

Referrals

(hasEvent)

[Pathway:R-HSA-8942233] Intestinal infectious diseases