Reactome | 26S proteasome degrades Ub-NFE2L2

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26S proteasome degrades Ub-NFE2L2 Show undefined attributes

authored	[InstanceEdit:8932363] Garapati, Phani Vijay, 2016-07-22
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category	uncertain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8932363] Garapati, Phani Vijay, 2016-07-22
dbId	8932355
displayName	26S proteasome degrades Ub-NFE2L2
edited	[InstanceEdit:8932363] Garapati, Phani Vijay, 2016-07-22
eventOf	[Pathway:R-HSA-9755511] KEAP1-NFE2L2 pathway - Homo sapiens [Pathway:R-HSA-8951664] Neddylation - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9758077] ub-NFE2L2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8932330] Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 [LiteratureReference:9708485] Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	26S proteasome degrades Ub-NFE2L2 Proteasomal degradation of NFE2L2
negativePrecedingEvent	[NegativePrecedingEvent:9767202] Abundant Molecules: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
orthologousEvent	[BlackBoxEvent:R-CEL-8932355] 26S proteasome degrades Ub-NFE2L2 - Caenorhabditis elegans [BlackBoxEvent:R-DME-8932355] 26S proteasome degrades Ub-NFE2L2 - Drosophila melanogaster [BlackBoxEvent:R-GGA-8932355] 26S proteasome degrades Ub-NFE2L2 - Gallus gallus [BlackBoxEvent:R-XTR-8932355] 26S proteasome degrades Ub-NFE2L2 - Xenopus tropicalis [BlackBoxEvent:R-DRE-8932355] 26S proteasome degrades Ub-NFE2L2 - Danio rerio [BlackBoxEvent:R-SSC-8932355] 26S proteasome degrades Ub-NFE2L2 - Sus scrofa [BlackBoxEvent:R-BTA-8932355] 26S proteasome degrades Ub-NFE2L2 - Bos taurus [BlackBoxEvent:R-CFA-8932355] 26S proteasome degrades Ub-NFE2L2 - Canis familiaris [BlackBoxEvent:R-RNO-8932355] 26S proteasome degrades Ub-NFE2L2 - Rattus norvegicus [BlackBoxEvent:R-MMU-8932355] 26S proteasome degrades Ub-NFE2L2 - Mus musculus
output	[DefinedSet:R-HSA-113595] Ub [cytosol]
precedingEvent	[Reaction:R-HSA-9758090] Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation - Homo sapiens
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9713327] Somers, Julia, 2021-01-23 [InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
revised	[InstanceEdit:9766710] Rothfels, Karen, 2022-02-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8932355
summation	[Summation:8932343] Ubiquitinated Nuclear factor erythroid 2-related (NFE2L2) un...
updateTrackers	[UpdateTracker:9775063] Update Tracker - [BlackBoxEvent:8932355] 26S proteasome degrades Ub-NFE2L2 - v80:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9775063] Update Tracker - [BlackBoxEvent:8932355] 26S proteasome degrades Ub-NFE2L2 - v80:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-8951664] Neddylation [Pathway:R-HSA-9755511] KEAP1-NFE2L2 pathway