26S proteasome degrades Ub-NFE2L2

Stable Identifier
R-HSA-8932355
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Synonyms
Proteasomal degradation of NFE2L2
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Ubiquitinated Nuclear factor erythroid 2-related (NFE2L2) undergoes proteasomal degradation and this maintains the protein level and activity at low levels. (Kobayashi et al, 2004; McMahon et al, 2003)

Literature References
PubMed ID Title Journal Year
12682069 Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

McMahon, M, Itoh, K, Yamamoto, M, Hayes, JD

J Biol Chem 2003
15282312 Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Kobayashi, A, Kang, MI, Okawa, H, Ohtsuji, M, Zenke, Y, Chiba, T, Igarashi, K, Yamamoto, M

Mol. Cell. Biol. 2004
Participants
Participates
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

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