Reactome | MET receptor recycling

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MET receptor recycling Show undefined attributes

authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
created	[InstanceEdit:8875667] Orlic-Milacic, Marija, 2016-06-08
crossReference	[DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175
dbId	8875656
displayName	MET receptor recycling
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
eventOf	[Pathway:R-HSA-6806834] Signaling by MET - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-8875661] GGA3 associates with activated MET receptor - Homo sapiens [BlackBoxEvent:R-HSA-8875659] RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8875664] GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration [LiteratureReference:8875784] Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation [LiteratureReference:8874693] Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein [LiteratureReference:8875449] The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met [LiteratureReference:8931776] Down-regulation of MET, the receptor for hepatocyte growth factor
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	MET receptor recycling
orthologousEvent	[Pathway:R-GGA-8875656] MET receptor recycling - Gallus gallus [Pathway:R-XTR-8875656] MET receptor recycling - Xenopus tropicalis [Pathway:R-DRE-8875656] MET receptor recycling - Danio rerio [Pathway:R-SSC-8875656] MET receptor recycling - Sus scrofa [Pathway:R-BTA-8875656] MET receptor recycling - Bos taurus [Pathway:R-CFA-8875656] MET receptor recycling - Canis familiaris [Pathway:R-RNO-8875656] MET receptor recycling - Rattus norvegicus [Pathway:R-MMU-8875656] MET receptor recycling - Mus musculus
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8875656
summation	[Summation:8875882] Activated MET receptor is subject to recycling from the plas...

Referrals

(hasEvent)

[Pathway:R-HSA-6806834] Signaling by MET