Reactome | MAPK12 phosphorylates PTPN3

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MAPK12 phosphorylates PTPN3 Show undefined attributes

authored	[InstanceEdit:8868081] Rothfels, Karen, 2016-04-18
catalystActivity	[CatalystActivity:8868115] protein serine/threonine kinase activity of PTPN3:p-T183,Y185-MAPK12 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8868119] Rothfels, Karen, 2016-04-19
dbId	8868118
displayName	MAPK12 phosphorylates PTPN3
edited	[InstanceEdit:8868081] Rothfels, Karen, 2016-04-18
eventOf	[Pathway:R-HSA-5675221] Negative regulation of MAPK pathway - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-8867651] PTPN3:p-T183,Y185-MAPK12 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8868108] p38? Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response [LiteratureReference:8867632] PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction [LiteratureReference:8867629] Essential role of p38gamma in K-Ras transformation independent of phosphorylation [LiteratureReference:8867646] Reciprocal allosteric regulation of p38? and PTPN3 involves a PDZ domain-modulated complex formation
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	MAPK12 phosphorylates PTPN3
orthologousEvent	[Reaction:R-CEL-8868118] MAPK12 phosphorylates PTPN3 - Caenorhabditis elegans [Reaction:R-DME-8868118] MAPK12 phosphorylates PTPN3 - Drosophila melanogaster [Reaction:R-GGA-8868118] MAPK12 phosphorylates PTPN3 - Gallus gallus [Reaction:R-XTR-8868118] MAPK12 phosphorylates PTPN3 - Xenopus tropicalis [Reaction:R-DRE-8868118] MAPK12 phosphorylates PTPN3 - Danio rerio [Reaction:R-SSC-8868118] MAPK12 phosphorylates PTPN3 - Sus scrofa [Reaction:R-BTA-8868118] MAPK12 phosphorylates PTPN3 - Bos taurus [Reaction:R-CFA-8868118] MAPK12 phosphorylates PTPN3 - Canis familiaris [Reaction:R-RNO-8868118] MAPK12 phosphorylates PTPN3 - Rattus norvegicus [Reaction:R-MMU-8868118] MAPK12 phosphorylates PTPN3 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-8868113] p-S459 PTPN3:p-T183,Y185-MAPK12 [cytosol]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8868118
summation	[Summation:8868117] PTPN3 has been shown to bind to phosphorylated MAPK12 and pr...

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(hasEvent)

[Pathway:R-HSA-5675221] Negative regulation of MAPK pathway