Reactome | PTPN3 binds p-T183,Y185 MAPK12

Schema > Reaction > Entries

PTPN3 binds p-T183,Y185 MAPK12 Show undefined attributes

authored	[InstanceEdit:8865229] Rothfels, Karen, 2016-03-21
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8867652] Rothfels, Karen, 2016-04-15
dbId	8867654
displayName	PTPN3 binds p-T183,Y185 MAPK12
edited	[InstanceEdit:8865229] Rothfels, Karen, 2016-03-21
eventOf	[Pathway:R-HSA-5675221] Negative regulation of MAPK pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-8867658] PTPN3 dephosphorylates MAPK12 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-171021] p-T183,Y185-MAPK12 [cytosol] [EntityWithAccessionedSequence:R-HSA-8867650] PTPN3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8867629] Essential role of p38gamma in K-Ras transformation independent of phosphorylation [LiteratureReference:8867632] PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction [LiteratureReference:8867646] Reciprocal allosteric regulation of p38? and PTPN3 involves a PDZ domain-modulated complex formation
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PTPN3 binds p-T183,Y185 MAPK12
orthologousEvent	[Reaction:R-CEL-8867654] PTPN3 binds p-T183,Y185 MAPK12 - Caenorhabditis elegans [Reaction:R-DME-8867654] PTPN3 binds p-T183,Y185 MAPK12 - Drosophila melanogaster [Reaction:R-GGA-8867654] PTPN3 binds p-T183,Y185 MAPK12 - Gallus gallus [Reaction:R-XTR-8867654] PTPN3 binds p-T183,Y185 MAPK12 - Xenopus tropicalis [Reaction:R-DRE-8867654] PTPN3 binds p-T183,Y185 MAPK12 - Danio rerio [Reaction:R-SSC-8867654] PTPN3 binds p-T183,Y185 MAPK12 - Sus scrofa [Reaction:R-BTA-8867654] PTPN3 binds p-T183,Y185 MAPK12 - Bos taurus [Reaction:R-CFA-8867654] PTPN3 binds p-T183,Y185 MAPK12 - Canis familiaris [Reaction:R-RNO-8867654] PTPN3 binds p-T183,Y185 MAPK12 - Rattus norvegicus [Reaction:R-MMU-8867654] PTPN3 binds p-T183,Y185 MAPK12 - Mus musculus
output	[Complex:R-HSA-8867651] PTPN3:p-T183,Y185-MAPK12 [cytosol]
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8867654
summation	[Summation:8867653] PTPN3 is a protein phosphatase that dephosphorylates MAPK12,...

Referrals

(precedingEvent)	[Reaction:R-HSA-8867658] PTPN3 dephosphorylates MAPK12
(hasEvent)	[Pathway:R-HSA-5675221] Negative regulation of MAPK pathway