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Schema
>
Reaction
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Entries
VLDLR:PCSK9 binds Clathrin-coated vesicles
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authored
[InstanceEdit:8855137] Jassal, Bijay, 2016-02-01
category
binding
compartment
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:8855137] Jassal, Bijay, 2016-02-01
dbId
8855131
displayName
VLDLR:PCSK9 binds Clathrin-coated vesicles
edited
[InstanceEdit:8855137] Jassal, Bijay, 2016-02-01
eventOf
[Pathway:R-HSA-8866427] VLDLR internalisation and degradation - Homo sapiens
input
[Complex:R-HSA-177505] Clathrin:AP-2 complex [plasma membrane]
[Complex:R-HSA-8855118] VLDL:PCSK9 [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8855117] The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2
[LiteratureReference:6784740] Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
VLDLR:PCSK9 binds Clathrin-coated vesicles
orthologousEvent
[Reaction:R-GGA-8855131] VLDLR:PCSK9 binds Clathrin-coated vesicles - Gallus gallus
[Reaction:R-XTR-8855131] VLDLR:PCSK9 binds Clathrin-coated vesicles - Xenopus tropicalis
[Reaction:R-SSC-8855131] VLDLR:PCSK9 binds Clathrin-coated vesicles - Sus scrofa
[Reaction:R-RNO-8855131] VLDLR:PCSK9 binds Clathrin-coated vesicles - Rattus norvegicus
[Reaction:R-MMU-8855131] VLDLR:PCSK9 binds Clathrin-coated vesicles - Mus musculus
output
[Complex:R-HSA-8855134] VLDL:PCSK9:Clathrin:AP2 [plasma membrane]
releaseDate
2016-06-15
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8866933] D'Eustachio, Peter, 2016-04-05
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8855131
summation
[Summation:8855142] Once proprotein convertase subtilisin/kexin type 9 (PCSK9) b...
Referrals
(hasEvent)
[Pathway:R-HSA-8866427] VLDLR internalisation and degradation
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