Reactome | VLDLR:PCSK9 binds Clathrin-coated vesicles

VLDLR:PCSK9 binds Clathrin-coated vesicles

Stable Identifier

R-HSA-8855131

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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VLDLR:PCSK9 binds Clathrin-coated vesicles

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Once proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to very low-density lipoprotein receptor (VLDLR), the resultant complex is internalised via the canonical clathrin-dependent endocytic machinery. This degradation route that does not require ubiquitination of the cytoplasmic tail of the receptor and does not involve proteasomal or autophagy pahtways (Zhang et al. 2007, Poirier et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18039658	The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2 Mayer, G, Nimpf, J, Benjannet, S, Poirier, S, Prat, A, Seidah, NG, Bergeron, E, Nassoury, N, Marcinkiewicz, J, Mayer, H	J. Biol. Chem.	2008
17452316	Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation Garuti, R, Hobbs, HH, Horton, JD, Zhao, Z, Cohen, JC, Zhang, DW, McDonald, M, Lagace, TA	J. Biol. Chem.	2007