Once proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to very low-density lipoprotein receptor (VLDLR), the resultant complex is internalised via the canonical clathrin-dependent endocytic machinery. This degradation route that does not require ubiquitination of the cytoplasmic tail of the receptor and does not involve proteasomal or autophagy pahtways (Zhang et al. 2007, Poirier et al. 2008).
Mayer, G, Nimpf, J, Benjannet, S, Poirier, S, Prat, A, Seidah, NG, Bergeron, E, Nassoury, N, Marcinkiewicz, J, Mayer, H
Garuti, R, Hobbs, HH, Horton, JD, Zhao, Z, Cohen, JC, Zhang, DW, McDonald, M, Lagace, TA
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