VLDLR:PCSK9 binds Clathrin-coated vesicles

Stable Identifier
Reaction [binding]
Homo sapiens
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Once proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to very low-density lipoprotein receptor (VLDLR), the resultant complex is internalised via the canonical clathrin-dependent endocytic machinery. This degradation route that does not require ubiquitination of the cytoplasmic tail of the receptor and does not involve proteasomal or autophagy pahtways (Zhang et al. 2007, Poirier et al. 2008).

Literature References
PubMed ID Title Journal Year
18039658 The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

Mayer, G, Nimpf, J, Benjannet, S, Poirier, S, Prat, A, Seidah, NG, Bergeron, E, Nassoury, N, Marcinkiewicz, J, Mayer, H

J. Biol. Chem. 2008
17452316 Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

Garuti, R, Hobbs, HH, Horton, JD, Zhao, Z, Cohen, JC, Zhang, DW, McDonald, M, Lagace, TA

J. Biol. Chem. 2007
Orthologous Events
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