Reactome | SCF-FBXL7 ubiquitinates AURKA

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SCF-FBXL7 ubiquitinates AURKA Show undefined attributes

authored	[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016-01-26
catalystActivity	[CatalystActivity:8854036] ubiquitin protein ligase activity of SCF-FBXL7:AURKA [cytosol]
catalystActivityReference	[CatalystActivityReference:9643432] ubiquitin protein ligase activity of SCF-FBXL7:AURKA [cytosol] Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8854035] Orlic-Milacic, Marija, 2016-01-26
dbId	8854041
displayName	SCF-FBXL7 ubiquitinates AURKA
edited	[InstanceEdit:8854049] Orlic-Milacic, Marija, 2016-01-26
eventOf	[Pathway:R-HSA-8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8854044] Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:422949] negative regulation of G2/M transition of mitotic cell cycle
input	[Complex:R-HSA-8854031] SCF-FBXL7:AURKA [cytosol] 3 × [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8853499] Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SCF-FBXL7 ubiquitinates AURKA
negativePrecedingEvent	[NegativePrecedingEvent:9764018] Futile Cycle: GTSE1 facilitates proteasome-mediated degradation of TP53 [NegativePrecedingEvent:9764040] Futile Cycle: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 [NegativePrecedingEvent:9764041] Futile Cycle: Proteasome-mediated degradation of PolyUb-FBXL7
orthologousEvent	[Reaction:R-PFA-8854041] SCF-FBXL7 ubiquitinates AURKA - Plasmodium falciparum [Reaction:R-DDI-8854041] SCF-FBXL7 ubiquitinates AURKA - Dictyostelium discoideum [Reaction:R-CEL-8854041] SCF-FBXL7 ubiquitinates AURKA - Caenorhabditis elegans [Reaction:R-DME-8854041] SCF-FBXL7 ubiquitinates AURKA - Drosophila melanogaster [Reaction:R-GGA-8854041] SCF-FBXL7 ubiquitinates AURKA - Gallus gallus [Reaction:R-DRE-8854041] SCF-FBXL7 ubiquitinates AURKA - Danio rerio [Reaction:R-SSC-8854041] SCF-FBXL7 ubiquitinates AURKA - Sus scrofa [Reaction:R-BTA-8854041] SCF-FBXL7 ubiquitinates AURKA - Bos taurus [Reaction:R-CFA-8854041] SCF-FBXL7 ubiquitinates AURKA - Canis familiaris [Reaction:R-RNO-8854041] SCF-FBXL7 ubiquitinates AURKA - Rattus norvegicus [Reaction:R-MMU-8854041] SCF-FBXL7 ubiquitinates AURKA - Mus musculus
output	[Complex:R-HSA-8854038] SCF-FBXL7:PolyUb-AURKA [cytosol]
precedingEvent	[Reaction:R-HSA-8853496] SCF:FBXL7 binds AURKA - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8874675] Grant, Rhys, 2016-05-13 [InstanceEdit:8874673] Lindon, Catherine, 2016-05-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8854041
summation	[Summation:8854037] The SCF-FBXL7 E3 ubiquitin ligase complex, composed of SKP1,...
updateTrackers	[UpdateTracker:9778176] Update Tracker - [Reaction:8854041] SCF-FBXL7 ubiquitinates AURKA - v68:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9778176] Update Tracker - [Reaction:8854041] SCF-FBXL7 ubiquitinates AURKA - v68:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
(precedingEvent)	[BlackBoxEvent:R-HSA-8854044] Proteasome degrades AURKA ubiquitinated by SCF-FBXL7