Reactome | NTPDase7 hydrolyzes nucleoside triphosphates

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NTPDase7 hydrolyzes nucleoside triphosphates Show undefined attributes

authored	[InstanceEdit:8850855] Orlic-Milacic, Marija, 2015-12-30
catalystActivity	[CatalystActivity:8851507] ribonucleoside triphosphate phosphatase activity of NTPDase7:Ca2+ [endocytic vesicle membrane]
catalystActivityReference	[CatalystActivityReference:9643824] nucleoside-triphosphatase activity of NTPDase7:Ca2+ [endocytic vesicle membrane] Molecular cloning and characterization of a novel mammalian endo-apyrase (LALP1)
category	transition
compartment	[Compartment:528865] endocytic vesicle lumen [Compartment:24337] endocytic vesicle membrane
created	[InstanceEdit:8851490] Orlic-Milacic, Marija, 2016-01-06
crossReference	[DatabaseIdentifier:12667807] RHEA:29388 [DatabaseIdentifier:12667809] RHEA:64901 [DatabaseIdentifier:12667808] RHEA:19670 [DatabaseIdentifier:9976520] RHEA:19670 [DatabaseIdentifier:9976499] RHEA:64901 [DatabaseIdentifier:9976514] RHEA:29388
dbId	8851494
displayName	NTPDase7 hydrolyzes nucleoside triphosphates
edited	[InstanceEdit:8850855] Orlic-Milacic, Marija, 2015-12-30
eventOf	[Pathway:R-HSA-8850843] Phosphate bond hydrolysis by NTPDase proteins - Homo sapiens
input	[DefinedSet:R-ALL-8851509] CTP,GTP,UTP [endocytic vesicle lumen] [SimpleEntity:R-ALL-8851517] H2O [endocytic vesicle lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8851482] Molecular cloning and characterization of a novel mammalian endo-apyrase (LALP1) [LiteratureReference:8851493] Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	NTPDase7 hydrolyzes nucleoside triphosphates CTP + H2O => CDP + phosphate + H(+) GTP + H2O => GDP + phosphate + H(+) UTP + H2O => UDP + phosphate + H(+)
orthologousEvent	[Reaction:R-PFA-8851494] NTPDase7 hydrolyzes nucleoside triphosphates - Plasmodium falciparum [Reaction:R-SCE-8851494] NTPDase7 hydrolyzes nucleoside triphosphates - Saccharomyces cerevisiae [Reaction:R-SPO-8851494] NTPDase7 hydrolyzes nucleoside triphosphates - Schizosaccharomyces pombe [Reaction:R-CEL-8851494] NTPDase7 hydrolyzes nucleoside triphosphates - Caenorhabditis elegans [Reaction:R-GGA-8851494] NTPDase7 hydrolyzes nucleoside triphosphates - Gallus gallus [Reaction:R-XTR-8851494] NTPDase7 hydrolyzes nucleoside triphosphates - Xenopus tropicalis [Reaction:R-SSC-8851494] NTPDase7 hydrolyzes nucleoside triphosphates - Sus scrofa [Reaction:R-BTA-8851494] NTPDase7 hydrolyzes nucleoside triphosphates - Bos taurus [Reaction:R-CFA-8851494] NTPDase7 hydrolyzes nucleoside triphosphates - Canis familiaris [Reaction:R-RNO-8851494] NTPDase7 hydrolyzes nucleoside triphosphates - Rattus norvegicus [Reaction:R-MMU-8851494] NTPDase7 hydrolyzes nucleoside triphosphates - Mus musculus
output	[DefinedSet:R-ALL-8851518] CDP,GDP,UDP [endocytic vesicle lumen] [SimpleEntity:R-ALL-5228597] H+ [endocytic vesicle lumen] [SimpleEntity:R-ALL-8851513] Pi [endocytic vesicle lumen]
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8870674] S�vigny, Jean, 2016-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8851494
summation	[Summation:8851524] NTPDase7 (LALP1), encoded by the ENTPD7 gene, is a cytoplasm...
updateTrackers	[UpdateTracker:9775865] Update Tracker - [Reaction:8851494] NTPDase7 hydrolyzes nucleoside triphosphates - v78:[addOutput]

Referrals

(updatedInstance)	[UpdateTracker:9775865] Update Tracker - [Reaction:8851494] NTPDase7 hydrolyzes nucleoside triphosphates - v78:[addOutput]
(hasEvent)	[Pathway:R-HSA-8850843] Phosphate bond hydrolysis by NTPDase proteins