Reactome | NTPDase7 hydrolyzes nucleoside triphosphates

NTPDase7 hydrolyzes nucleoside triphosphates

Stable Identifier

R-HSA-8851494

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endocytic vesicle lumen, endocytic vesicle membrane

ReviewStatus

5/5

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NTPDase7 hydrolyzes nucleoside triphosphates

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NTPDase7 (LALP1), encoded by the ENTPD7 gene, is a cytoplasmic vesicle membrane-bound nucleotide phosphatase that hydrolyzes nucleoside triphosphates CTP, GTP and UTP to nucleoside diphosphates CDP, GDP and UDP, respectively. NTPDase7 may have a low activity towards ATP and nucleoside diphosphates (Shi et al. 2001). NTPDase7 requires Ca2+ for catalytic activity (Shi et al. 2001). In mice, NTPDase7 was shown to regulate development of IL17-secreting Th17 cells in the small intestine, possibly by regulating extracellular ATP levels (Kusu et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
11278936	Molecular cloning and characterization of a novel mammalian endo-apyrase (LALP1) Cruz, PE, Lian, W, Wu, DH, Kukar, T, Gu, Y, Wang, CY, Li, QZ, Davoodi-Semiromi, A, She, JX, Shi, JD, Yang, P	J. Biol. Chem.	2001
23241884	Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine Okumura, R, Takeda, K, Nishimura, J, Saiga, H, Goto, Y, Honda, K, Maeda, Y, Kunisawa, J, Yamamoto, M, Arima, Y, Jeon, SG, Ikeda, K, Atarashi, K, Kayama, H, Kurakawa, T, Kiyono, H, Okumura, M, Murakami, M, Ueda, Y, Kinoshita, M, Kusu, T	J. Immunol.	2013