NTPDase7 hydrolyzes nucleoside triphosphates

Stable Identifier
R-HSA-8851494
Type
Reaction
Species
Homo sapiens
Compartment
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NTPDase7 (LALP1), encoded by the ENTPD7 gene, is a cytoplasmic vesicle membrane-bound nucleotide phosphatase that hydrolyzes nucleoside triphosphates CTP, GTP and UTP to nucleoside diphosphates CDP, GDP and UDP, respectively. NTPDase7 may have a low activity towards ATP and nucleoside diphosphates (Shi et al. 2001). NTPDase7 requires Ca2+ for catalytic activity (Shi et al. 2001). In mice, NTPDase7 was shown to regulate development of IL17-secreting Th17 cells in the small intestine, possibly by regulating extracellular ATP levels (Kusu et al. 2013).

Literature References
PubMed ID Title Journal Year
11278936 Molecular cloning and characterization of a novel mammalian endo-apyrase (LALP1)

Cruz, PE, Lian, W, Wu, DH, Kukar, T, Gu, Y, Wang, CY, Li, QZ, Davoodi-Semiromi, A, She, JX, Shi, JD, Yang, P

J. Biol. Chem. 2001
23241884 Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine

Okumura, R, Takeda, K, Nishimura, J, Saiga, H, Goto, Y, Honda, K, Maeda, Y, Kunisawa, J, Yamamoto, M, Arima, Y, Jeon, SG, Ikeda, K, Atarashi, K, Kayama, H, Kurakawa, T, Kiyono, H, Okumura, M, Murakami, M, Ueda, Y, Kinoshita, M, Kusu, T

J. Immunol. 2013
Participants
Participates
Catalyst Activity

nucleoside-triphosphatase activity of NTPDase7:Ca2+ [endocytic vesicle membrane]

Orthologous Events
Cross References
Rhea
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