Reactome | NTPDase3 hydrolyzes nucleoside triphosphates

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NTPDase3 hydrolyzes nucleoside triphosphates Show undefined attributes

authored	[InstanceEdit:8850855] Orlic-Milacic, Marija, 2015-12-30
catalystActivity	[CatalystActivity:8851106] ribonucleoside triphosphate phosphatase activity of NTPDase3:Ca2+,Mg2+ [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8851112] Orlic-Milacic, Marija, 2016-01-05
crossReference	[DatabaseIdentifier:12667806] RHEA:23681 [DatabaseIdentifier:9976523] RHEA:23681
dbId	8851110
displayName	NTPDase3 hydrolyzes nucleoside triphosphates
edited	[InstanceEdit:8850855] Orlic-Milacic, Marija, 2015-12-30
eventOf	[Pathway:R-HSA-8850843] Phosphate bond hydrolysis by NTPDase proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-8851129] NTPDase3 hydrolyzes nucleoside diphosphates - Homo sapiens
input	[SimpleEntity:R-ALL-109276] H2O [extracellular region] [SimpleEntity:R-ALL-8870907] NTP [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8851120] Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1 [LiteratureReference:8870955] Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8 [LiteratureReference:8871000] Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-3 [LiteratureReference:8870996] Identification of the ectonucleotidases expressed in mouse, rat, and human Langerhans islets: potential role of NTPDase3 in insulin secretion [LiteratureReference:8870994] Immunolocalization of ecto-nucleoside triphosphate diphosphohydrolase 3 in rat brain: implications for modulation of multiple homeostatic systems including feeding and sleep-wake behaviors
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	NTPDase3 hydrolyzes nucleoside triphosphates a ribonucleoside 5'-triphosphate + H2O => a ribonucleoside 5'-diphosphate + phosphate + H(+)
orthologousEvent	[Reaction:R-PFA-8851110] NTPDase3 hydrolyzes nucleoside triphosphates - Plasmodium falciparum [Reaction:R-SCE-8851110] NTPDase3 hydrolyzes nucleoside triphosphates - Saccharomyces cerevisiae [Reaction:R-SPO-8851110] NTPDase3 hydrolyzes nucleoside triphosphates - Schizosaccharomyces pombe [Reaction:R-GGA-8851110] NTPDase3 hydrolyzes nucleoside triphosphates - Gallus gallus [Reaction:R-XTR-8851110] NTPDase3 hydrolyzes nucleoside triphosphates - Xenopus tropicalis [Reaction:R-SSC-8851110] NTPDase3 hydrolyzes nucleoside triphosphates - Sus scrofa [Reaction:R-BTA-8851110] NTPDase3 hydrolyzes nucleoside triphosphates - Bos taurus [Reaction:R-CFA-8851110] NTPDase3 hydrolyzes nucleoside triphosphates - Canis familiaris [Reaction:R-RNO-8851110] NTPDase3 hydrolyzes nucleoside triphosphates - Rattus norvegicus [Reaction:R-MMU-8851110] NTPDase3 hydrolyzes nucleoside triphosphates - Mus musculus
output	[SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-8870906] NDP [extracellular region] [SimpleEntity:R-ALL-109277] Pi [extracellular region]
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8870674] S�vigny, Jean, 2016-05-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8851110
summation	[Summation:8851119] NTPDase3 (CD39L3), encoded by the ENTPD3 gene, is a plasma m...
updateTrackers	[UpdateTracker:9775610] Update Tracker - [Reaction:8851110] NTPDase3 hydrolyzes nucleoside triphosphates - v78:[addOutput]

Referrals

(updatedInstance)	[UpdateTracker:9775610] Update Tracker - [Reaction:8851110] NTPDase3 hydrolyzes nucleoside triphosphates - v78:[addOutput]
(precedingEvent)	[Reaction:R-HSA-8851129] NTPDase3 hydrolyzes nucleoside diphosphates
(hasEvent)	[Pathway:R-HSA-8850843] Phosphate bond hydrolysis by NTPDase proteins