NTPDase3 hydrolyzes nucleoside triphosphates

Stable Identifier
Reaction [transition]
Homo sapiens
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NTPDase3 (CD39L3), encoded by the ENTPD3 gene, is a plasma membrane-bound ectonucleotidase that hydrolyzes extracellular NTPs to NMPs via corresponding NDP intermediates (Smith and Kirley 1998, Lavoie et al. 2004, Kukulski et al. 2005). NTPDase3 is about 3 times more efficient in hydrolyzing ATP than ADP (Smith and Kirley 1998). NTPDase3 is expressed in some neurons (Belcher et al. 2006, Lavoie et al. 2010) where it may be involved in sleep-wake behaviour (Belcher et al. 2006). NTPDase3 is also expressed in islet cells where it may regulate insulin secretion (Lavoie et al. 2010).

Literature References
PubMed ID Title Journal Year
15130768 Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-3

Lecka, J, Sévigny, J, Kukulski, F, Lavoie, EG, Lévesque, SA

Biochem. Pharmacol. 2004
18404504 Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8

Lavoie, EG, Lévesque, SA, Sévigny, J, Kukulski, F, Kirley, TL, Robson, SC, Bigonnesse, F, Lecka, J, Knowles, AF

Purinergic Signal. 2005
9675246 Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1

Kirley, TL, Smith, TM

Biochim. Biophys. Acta 1998
16338080 Immunolocalization of ecto-nucleoside triphosphate diphosphohydrolase 3 in rat brain: implications for modulation of multiple homeostatic systems including feeding and sleep-wake behaviors

Crawford, PA, Zsarnovszky, A, Hemani, H, Kirley, TL, Spurling, L, Belcher, SM

Neuroscience 2006
20682839 Identification of the ectonucleotidases expressed in mouse, rat, and human Langerhans islets: potential role of NTPDase3 in insulin secretion

Kauffenstein, G, Sévigny, J, Friess, H, Kukulski, F, Fausther, M, Künzli, BM, Lavoie, EG

Am. J. Physiol. Endocrinol. Metab. 2010
Catalyst Activity

nucleoside-triphosphatase activity of NTPDase3:Ca2+,Mg2+ [plasma membrane]

Orthologous Events
Cross References
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