Reactome | NTPDase3 hydrolyzes nucleoside triphosphates

NTPDase3 hydrolyzes nucleoside triphosphates

Stable Identifier

R-HSA-8851110

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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NTPDase3 hydrolyzes nucleoside triphosphates

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NTPDase3 (CD39L3), encoded by the ENTPD3 gene, is a plasma membrane-bound ectonucleotidase that hydrolyzes extracellular NTPs to NMPs via corresponding NDP intermediates (Smith and Kirley 1998, Lavoie et al. 2004, Kukulski et al. 2005). NTPDase3 is about 3 times more efficient in hydrolyzing ATP than ADP (Smith and Kirley 1998). NTPDase3 is expressed in some neurons (Belcher et al. 2006, Lavoie et al. 2010) where it may be involved in sleep-wake behaviour (Belcher et al. 2006). NTPDase3 is also expressed in islet cells where it may regulate insulin secretion (Lavoie et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
15130768	Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-3 Lecka, J, Sévigny, J, Kukulski, F, Lavoie, EG, Lévesque, SA	Biochem. Pharmacol.	2004
18404504	Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8 Lavoie, EG, Lévesque, SA, Sévigny, J, Kukulski, F, Kirley, TL, Robson, SC, Bigonnesse, F, Lecka, J, Knowles, AF	Purinergic Signal.	2005
9675246	Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1 Kirley, TL, Smith, TM	Biochim. Biophys. Acta	1998
16338080	Immunolocalization of ecto-nucleoside triphosphate diphosphohydrolase 3 in rat brain: implications for modulation of multiple homeostatic systems including feeding and sleep-wake behaviors Crawford, PA, Zsarnovszky, A, Hemani, H, Kirley, TL, Spurling, L, Belcher, SM	Neuroscience	2006
20682839	Identification of the ectonucleotidases expressed in mouse, rat, and human Langerhans islets: potential role of NTPDase3 in insulin secretion Kauffenstein, G, Sévigny, J, Friess, H, Kukulski, F, Fausther, M, Künzli, BM, Lavoie, EG	Am. J. Physiol. Endocrinol. Metab.	2010