Reactome | CYTH proteins bind ARF1:GTP

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CYTH proteins bind ARF1:GTP Show undefined attributes

authored	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
category	binding
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:8847879] Rothfels, Karen, 2015-12-02
dbId	8847880
displayName	CYTH proteins bind ARF1:GTP
edited	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
eventOf	[Pathway:R-HSA-6811438] Intra-Golgi traffic - Homo sapiens
followingEvent	[Reaction:R-HSA-8847883] CYTH proteins stimulate ARF1 GTPase activity - Homo sapiens
input	[Complex:R-HSA-1806286] ARF1:GTP [Golgi membrane] [DefinedSet:R-HSA-8847857] CYTH1,2,3,4 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8847820] A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains [LiteratureReference:8847777] Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1 [LiteratureReference:8847761] Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase [LiteratureReference:8847767] Structure of the Sec7 domain of the Arf exchange factor ARNO [LiteratureReference:8847814] ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function [LiteratureReference:8847790] Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors [LiteratureReference:8847774] Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	CYTH proteins bind ARF1:GTP
orthologousEvent	[Reaction:R-PFA-8847880] CYTH proteins bind ARF1:GTP - Plasmodium falciparum [Reaction:R-SCE-8847880] CYTH proteins bind ARF1:GTP - Saccharomyces cerevisiae [Reaction:R-SPO-8847880] CYTH proteins bind ARF1:GTP - Schizosaccharomyces pombe [Reaction:R-DDI-8847880] CYTH proteins bind ARF1:GTP - Dictyostelium discoideum [Reaction:R-CEL-8847880] CYTH proteins bind ARF1:GTP - Caenorhabditis elegans [Reaction:R-DME-8847880] CYTH proteins bind ARF1:GTP - Drosophila melanogaster [Reaction:R-XTR-8847880] CYTH proteins bind ARF1:GTP - Xenopus tropicalis [Reaction:R-DRE-8847880] CYTH proteins bind ARF1:GTP - Danio rerio [Reaction:R-SSC-8847880] CYTH proteins bind ARF1:GTP - Sus scrofa [Reaction:R-BTA-8847880] CYTH proteins bind ARF1:GTP - Bos taurus [Reaction:R-CFA-8847880] CYTH proteins bind ARF1:GTP - Canis familiaris [Reaction:R-RNO-8847880] CYTH proteins bind ARF1:GTP - Rattus norvegicus [Reaction:R-MMU-8847880] CYTH proteins bind ARF1:GTP - Mus musculus
output	[Complex:R-HSA-8847867] ARF1:GTP:CYTH1,2,3,4 [Golgi membrane]
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855182] Gillespie, Marc E, 2016-02-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8847880
summation	[Summation:8847878] Cytohesin (CYTH) proteins 1, 2, 3 and 4 are ARF guanine nucl...

Referrals

(hasEvent)	[Pathway:R-HSA-6811438] Intra-Golgi traffic
(precedingEvent)	[Reaction:R-HSA-8847883] CYTH proteins stimulate ARF1 GTPase activity

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